SphK1&2-IN-1
Based on 1 Customer Validation
SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability.
For research use only. We do not sell to patients.
- Purity: 98.47%
- CAS No.: 1415662-57-5
- Formula: C14H14N2O3S
- Molecular Weight:290.34
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Kinase Inhibitor Library
HY-L009
-
Anti-Cancer Compound Library
HY-L025
-
Covalent Screening Library
HY-L036
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Cysteine Targeted Covalent Library
HY-L153
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
Biological Activity
|
SphK1 |
SphK2 |
SphK1&2-IN-1 (compound 40) (10 μM) inhibits SphK1 and SphK2 with inhibition rates of 14.3% and 26.5%, respectively[1].
SphK1&2-IN-1 (compound W4) (1-100 μM) has good thermal stability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1415662-57-5
-
Appearance Solid
-
Molecular Weight 290.34
-
Formula C14H14N2O3S
-
Color Off-white to light yellow
-
SMILES
COC1=C(C=CC(/C=C/C(NC2=NC=CS2)=O)=C1)OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 31.25 mg/mL (107.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
[1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. [Content Brief]
[2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4442 mL | 17.2212 mL | 34.4424 mL | 86.1059 mL |
| 5 mM | 0.6888 mL | 3.4442 mL | 6.8885 mL | 17.2212 mL | |
| 10 mM | 0.3444 mL | 1.7221 mL | 3.4442 mL | 8.6106 mL | |
| 15 mM | 0.2296 mL | 1.1481 mL | 2.2962 mL | 5.7404 mL | |
| 20 mM | 0.1722 mL | 0.8611 mL | 1.7221 mL | 4.3053 mL | |
| 25 mM | 0.1378 mL | 0.6888 mL | 1.3777 mL | 3.4442 mL | |
| 30 mM | 0.1148 mL | 0.5740 mL | 1.1481 mL | 2.8702 mL | |
| 40 mM | 0.0861 mL | 0.4305 mL | 0.8611 mL | 2.1526 mL | |
| 50 mM | 0.0689 mL | 0.3444 mL | 0.6888 mL | 1.7221 mL | |
| 60 mM | 0.0574 mL | 0.2870 mL | 0.5740 mL | 1.4351 mL | |
| 80 mM | 0.0431 mL | 0.2153 mL | 0.4305 mL | 1.0763 mL | |
| 100 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8611 mL |
Powered by Bioz