2. Immunology/Inflammation
  3. SphK
  4. SphK2-IN-1

SphK2-IN-1 is a SphK2 inhibitor (IC50: 0.359 μM). SphK2-IN-1 can be used in the research of cancer, inflammation, neurological and cardiovascular disorders.

For research use only. We do not sell to patients.

SphK2-IN-1 Chemical Structure

SphK2-IN-1 Chemical Structure

CAS No. : 2927429-64-7

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SphK2-IN-1 Related Antibodies

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Description

SphK2-IN-1 is a SphK2 inhibitor (IC50: 0.359 μM). SphK2-IN-1 can be used in the research of cancer, inflammation, neurological and cardiovascular disorders[1].

IC50 & Target[1]

SphK2

0.359 μM (IC50)

In Vitro

SphK2-IN-1 (compound 25b, 125 µM, 24 h) inhibits cell viability against U-251 MG human glioblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SphK2-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: U-251 MG human glioblastoma cells
Concentration: 125 µM
Incubation Time: 24 h
Result: Decreased cell viability by more than 80%.
Molecular Weight

518.92

Formula

C23H22ClF3N8O
CAS No.
SMILES

N=C(N1CCC[C@H]1C2=NC(C3=CC=C(C=C3)CN4C=C(N=N4)C5=CC=C(C=C5)C(F)(F)F)=NO2)N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SphK2-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SphK2-IN-12927429-64-7SphKSphingosine kinaseADP-GloU-251glioblastomacancerinflammationInhibitorinhibitorinhibit

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