Pde8a - phosphodiesterase 8A Gene

Also Known as RNPDE8A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308776

About Pde8a

Primary_assembly 1: 135,166,237-135,288,024 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 220 orthologues, 20 paralogues and is associated with 2 phenotypes. Biased expression in Adrenal (RPKM 166.4), Kidney (RPKM 127.3) and 9 other tissues.

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and kinase binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Apr 2022]

Pde8a Products (1)

mRNA Protein Name
NM_198767.1 NP_942062.1 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Pde8a Protein Structure

PDE8

PDE8: cl07304 (0 - 23)

PAS

PAS: COG2202 (117 - 317)

PAS_9

PAS_9: pfam13426 (219 - 317)

PDEase_I

PDEase_I: pfam00233 (547 - 799)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
Protein Preferred Names Protein Names

high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

  • cAMP-specific cyclic nucleotide phosphodiesterase PDE8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15426 PF-04957325 Inhibitor 99.55% Unkown
HY-134937 BC8-15 Inhibitor / Unkown
HY-179503 PDE/TRPA1/CHIT1-IN-1 Inhibitor / Unkown
HY-RS10242 PDE8A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10243 Pde8a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10244 Pde8a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde8a NCBI NCBI:5151