Cdk19 - cyclin-dependent kinase 19 Gene

Also Known as Cdk11; Cdc2l6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309804

About Cdk19

Primary_assembly 20: 43,770,409-43,910,628 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 207 orthologues, 24 paralogues and is associated with 4 phenotypes. Biased expression in Thymus (RPKM 138.4), Spleen (RPKM 11.7) and 9 other tissues.

Summary

Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in cellular response to lipopolysaccharide; positive regulation of apoptotic process; and positive regulation of inflammatory response. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 87. Orthologous to human CDK19 (cyclin dependent kinase 19). [provided by Alliance of Genome Resources, Apr 2022]

Cdk19 Products (1)

mRNA Protein Name
NM_001107634.1 NP_001101104.1 cyclin-dependent kinase 19

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20066559 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23703121 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk19 Protein Structure

STKc_CDC2L6

STKc_CDC2L6: cd07867 (17 - 334)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 19

  • cell division cycle 2-like 6 (CDK8-like)

  • cell division protein kinase 19

  • cyclin-dependent kinase (CDC2-like) 11

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101800 Senexin B Inhibitor 99.09% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126675A AS2863619 Inhibitor 98.02% Unkown
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% Unkown
HY-15681 Senexin A Inhibitor 99.58% Unkown
HY-19984 CCT-251921 Inhibitor 99.12% Unkown
HY-122586 BRD6989 Inhibitor 99.54% Unkown
HY-156366 SNX7886 Degrader 99.71% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.87% Unkown
HY-143889 Senexin C Inhibitor 99.19% Unkown
HY-168683 CDK8 ligand 1 Degrader 99.88% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% Unkown
HY-111388 SEL120-34A Inhibitor 99.49% Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-D2311 CDK19 Probe 1 / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-168846 CDK8/19-IN-3 Inhibitor / Unkown
HY-158377 CDK8/19-IN-2 Inhibitor / Unkown
HY-183074 RO8323 Inhibitor / Unkown
HY-184544 CDK8 ligand 2 / Unkown
HY-171174 CDK8-IN-16 Inhibitor / Unkown
HY-183423 MK256 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk19 NCBI NCBI:23097