Atg7 - autophagy related 7 Gene

Also Known as Apg7l

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312647

Summary

Predicted to enable Atg12 activating enzyme activity; Atg8 activating enzyme activity; and protein homodimerization activity. Involved in several processes, including cellular response to morphine; negative regulation of mitochondrial DNA replication; and negative regulation of oxidative stress-induced neuron death. Located in axon. Used to study high grade glioma. Biomarker of hypertension; myocardial infarction; neurodegenerative disease; and paraplegia. Human ortholog(s) of this gene implicated in autosomal recessive cerebellar ataxia. Orthologous to human Atg7 (Autophagy related 7). [provided by Alliance of Genome Resources, Apr 2022]

Atg7 Products (1)

mRNA Protein Name
NM_001012097.1 NP_001012097.1 ubiquitin-like modifier-activating enzyme ATG7

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to morphine IEP
IEP: Inferred from expression pattern
23800874 RGD
involved in cellular response to sodium arsenite IMP
IMP: Inferred from mutant phenotype
25639566 RGD
involved in chaperone-mediated autophagy IMP
IMP: Inferred from mutant phenotype
23434281 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
25241190 RGD
involved in negative regulation of mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
23800874 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
23800795 RGD
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
24674959 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25639566 RGD
involved in positive regulation of programmed cell death IMP
IMP: Inferred from mutant phenotype
25639566 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
24226028 RGD
involved in response to fluoride IEP
IEP: Inferred from expression pattern
24296261 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
21384092 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17665967 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
25040536 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme ATG7

  • ATG12-activating enzyme E1 ATG7

  • ATG7 autophagy related 7 homolog

  • autophagy 7-like

  • autophagy related 7 homolog

  • autophagy-related protein 7

  • ubiquitin-activating enzyme E1-like protein

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0538 Xylitol Activator 99.5% Yes

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146130 ATG7-IN-2 99.32% Unkown
HY-145371 ATG7-IN-1 Inhibitor 99.84% Unkown
HY-146131 ATG7-IN-3 99.26% Unkown
HY-W768347 Xylitol-13C5 / Unkown
HY-184501 UE01 / Unkown
HY-179052 Apoptosis inducer 50 Activator / Unkown
HY-N13352 Bufothionine Activator / Unkown
HY-151914 Antitumor agent-82 / Unkown
HY-173133 Antitumor agent-199 Activator / Unkown
HY-170594 Antitumor agent-192 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atg7 NCBI NCBI:10533