Rdx - radixin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 315655

Summary

Enables actin binding activity. Involved in apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]

Rdx Products (1)

mRNA Protein Name
NM_001005889.2 NP_001005889.2 radixin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
2500445 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7844168 RGD
enables protein kinase A binding IMP
IMP: Inferred from mutant phenotype
21047789 RGD
Biological Process GO Annotation Evidence References Source
involved in apical protein localization IMP
IMP: Inferred from mutant phenotype
16952556 RGD
involved in barbed-end actin filament capping IDA
IDA: Inferred from direct assay
2500445 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
8647942 RGD
involved in cellular response to thyroid hormone stimulus IMP
IMP: Inferred from mutant phenotype
21047789 RGD
involved in establishment of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
21047789 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21047789 RGD
involved in protein kinase A signaling IMP
IMP: Inferred from mutant phenotype
21047789 RGD
involved in regulation of Rap protein signal transduction IMP
IMP: Inferred from mutant phenotype
21047789 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
19028724 RGD
located in adherens junction IDA
IDA: Inferred from direct assay
2500445 RGD
located in cell tip IDA
IDA: Inferred from direct assay
17061246 RGD
located in cleavage furrow IDA
IDA: Inferred from direct assay
1707055 RGD
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
21047789 RGD
located in filopodium IDA
IDA: Inferred from direct assay
21047789 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
21047789 RGD
located in microvillus IDA
IDA: Inferred from direct assay
11438984 RGD
located in midbody IDA
IDA: Inferred from direct assay
1707055 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21047789 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

radixin

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15991 Tenapanor Inhibitor 99.65% Unkown
HY-15991A Tenapanor hydrochloride Inhibitor 99.55% Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13631J (1R,9R)-Exatecan mesylate 99.49% Unkown
HY-13631I (1S,9R)-Exatecan mesylate 99.11% Unkown
HY-P2800 Diaphorase, Recombinant microorganisms / Unkown
HY-RS11806 RDX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18121 Rdx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24595 Rdx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rdx NCBI NCBI:5962
Mus musculus Rdx NCBI NCBI:19684