Itpkb - inositol 1,4,5-trisphosphate 3-kinase B Gene

Also Known as 1110033J02Rik; E130307H12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 320404

Summary

Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Apr 2022]

Itpkb Products (1)

mRNA Protein Name
NM_001081175.1 NP_001074644.1 inositol-trisphosphate 3-kinase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
IDA: Inferred from direct assay
14517551 MGI
enables inositol-1,4,5-trisphosphate 3-kinase activity IMP
IMP: Inferred from mutant phenotype
15064401 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
15064401 MGI
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
14517551 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15064401 MGI
acts upstream of or within common myeloid progenitor cell proliferation IMP
IMP: Inferred from mutant phenotype
18339802 MGI
acts upstream of or within myeloid cell homeostasis IMP
IMP: Inferred from mutant phenotype
18339802 MGI
acts upstream of or within negative regulation of myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
18339802 MGI
acts upstream of or within negative regulation of neutrophil apoptotic process IMP
IMP: Inferred from mutant phenotype
18339802 MGI
acts upstream of or within positive regulation of Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
15064401 MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
15064401 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
15064401 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
18339802 MGI
acts upstream of or within thymic T cell selection IMP
IMP: Inferred from mutant phenotype
14517551 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
15381088 MGI
located in membrane IDA
IDA: Inferred from direct assay
15381088 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15381088 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol-trisphosphate 3-kinase B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126750 GNF362 Inhibitor 99.86% Unkown
HY-RS06989 ITPKB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19451 Itpkb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25943 Itpkb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpkb NCBI NCBI:3707