Mapk15 - mitogen-activated protein kinase 15 Gene

Also Known as ERK-8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 332110

About Mapk15

Chromosome 15: 75,865,618-75,871,003 forward strand.GRCm39:CM001008.3

This gene has 5 transcripts (splice variants), 197 orthologues, 19 paralogues and is associated with 7 phenotypes. Biased expression in testis adult (RPKM 48.8), lung adult (RPKM 26.9) and 8 other tissues.

Summary

Predicted to enable MAP kinase activity and chromatin binding activity. Involved in positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; and regulation of cilium assembly. Located in meiotic spindle. Is expressed in several structures, including brain; genitourinary system; limb; nose; and viscerocranium. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Apr 2022]

Mapk15 Products (1)

mRNA Protein Name
NM_177922.2 NP_808590.1 mitogen-activated protein kinase 15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25823377 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of metaphase/anaphase transition of meiosis I IMP
IMP: Inferred from mutant phenotype
23351492 MGI
involved in positive regulation of spindle assembly IMP
IMP: Inferred from mutant phenotype
23351492 MGI
involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
25823377 MGI
Cellular Component GO Annotation Evidence References Source
located in meiotic spindle IDA
IDA: Inferred from direct assay
23351492 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk15 Protein Structure

STKc_MAPK15-like

STKc_MAPK15-like: cd07852 (5 - 343)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 549 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 15

  • ERK-7

  • MAP kinase 15

  • MAPK 15

  • extracellular signal-regulated kinase 7

  • extracellular signal-regulated kinase 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135906 CK2/ERK8-IN-1 99.0% Unkown
HY-RS08110 MAPK15 Human Pre-designed siRNA Set A / Unkown
HY-RS08111 Mapk15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08112 Mapk15 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk15 NCBI NCBI:225689