Brca2 - BRCA2, DNA repair associated Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360254

Summary

Enables single-stranded DNA binding activity. Involved in several processes, including homologous chromosome orientation involved in meiotic metaphase I plate congression; response to estradiol; and spermatogenesis. Predicted to be located in several cellular components, including centrosome; chromosome, telomeric region; and nuclear lumen. Predicted to be part of BRCA2-MAGE-D1 complex. Predicted to be active in nucleus. Used to study atrophy of testis; cancer; cataract; infertility; and osteosarcoma. Biomarker of ductal carcinoma in situ and prostate Cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain Cancer (multiple); hereditary breast ovarian Cancer syndrome; melanoma (multiple); and reproductive organ Cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca2 Products (1)

mRNA Protein Name
NM_031542.2 NP_113730.2 breast cancer type 2 susceptibility protein homolog

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12228710 RGD
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
12228710 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA recombination IDA
IDA: Inferred from direct assay
12228710 RGD
involved in homologous chromosome orientation in meiotic metaphase I IMP
IMP: Inferred from mutant phenotype
16964288 RGD
involved in mammary gland development IMP
IMP: Inferred from mutant phenotype
16964288 RGD
involved in multicellular organism growth IMP
IMP: Inferred from mutant phenotype
16964288 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14583453 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
14583453 RGD
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
16964288 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

breast cancer type 2 susceptibility protein homolog

  • breast cancer 2, early onset

  • breast cancer 2, mutation 1, University of Wisconsin-Madison

  • breast cancer susceptibility protein 2

  • fanconi anemia group D1 protein homolog

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10617A Rucaparib Inhibitor 99.96% Yes
HY-10617 Rucaparib phosphate Inhibitor 99.76% Yes
HY-102003 Rucaparib monocamsylate Inhibitor 99.91% Yes
HY-102003A Rucaparib camsylate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-115552 Simmiparib Inhibitor 99.01% Phase 1

Pre-clinical Phase

Bioactive Molecules (36)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124691 D-I03 Inhibitor 99.70% Unkown
HY-151462 RP-6685 Inhibitor 99.96% Unkown
HY-150147 CAM833 99.83% Unkown
HY-170844 MU147 Inhibitor 99.35% Unkown
HY-122639 ZINC05007751 99.33% Unkown
HY-162706 BSJ-5-63 Degrader 99.97% Unkown
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% Unkown
HY-40041 (R)-1-Boc-3-methyl-piperazine 99.86% Unkown
HY-161431 RTx-152 99.71% Unkown
HY-168993 BRCA2-IN-2 Inhibitor 97.30% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-170845 MU1409 Inhibitor 98.52% Unkown
HY-135782A iso-ADP ribose TEA 99.97% Unkown
HY-181557 SY-589 98.50% Unkown
HY-135782 iso-ADP ribose / Unkown
HY-153338 C791-0064 99.15% Unkown
HY-158346 RP-2119 Inhibitor 99.94% Unkown
HY-RS01594 BRCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179219S RTx-303 Inhibitor / Unkown
HY-10617AS1 Rucaparib-d3 Inhibitor / Unkown
HY-122583 D-G23 Inhibitor / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-150958 RAD51-IN-8 / Unkown
HY-153755 ART6043 Inhibitor / Unkown
HY-155766 PARP1-IN-14 / Unkown
HY-163816 Antiproliferative agent-53-d3 Inhibitor / Unkown
HY-168094 PARP1-IN-30 Inhibitor / Unkown
HY-173151 BRCA2-IN-1 Inhibitor / Unkown
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / Unkown
HY-179413 Polθ-IN-9 Inhibitor / Unkown
HY-182322 POLQ-IN-1 Inhibitor / Unkown
HY-P10516 BRC4 peptide / Unkown
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / Unkown
HY-181561 BRCA2-RAD51-IN-3 Inhibitor / Unkown
HY-RS16825 Brca2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23267 Brca2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brca2 NCBI NCBI:675