Map1lc3a - microtubule-associated protein 1 light chain 3 alpha Gene

Also Known as LC3A; LC3-I; LC3-II

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362245

Summary

Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; cellular response to copper ion; and response to morphine. Located in autophagosome membrane; cytosol; and late endosome. Is active in synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Map1lc3a Products (1)

mRNA Protein Name
NM_199500.2 NP_955794.1 microtubule-associated proteins 1A/1B light chain 3A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22421968 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in SMAD protein signal transduction IDA
IDA: Inferred from direct assay
27769861 RGD
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
11060023 RGD
involved in autophagy IDA
IDA: Inferred from direct assay
16420522 RGD
involved in cellular response to amino acid starvation IEP
IEP: Inferred from expression pattern
22835012 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
22540380 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
23314838 RGD
involved in cellular response to oxygen-glucose deprivation IEP
IEP: Inferred from expression pattern
27769861 RGD
involved in p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
27769861 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
23187302 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
22927075 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17665967 RGD
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
11060023 RGD
located in autophagosome membrane IDA
IDA: Inferred from direct assay
16300744 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
11060023 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15095872 RGD
located in late endosome IDA
IDA: Inferred from direct assay
19337031 RGD
located in organelle membrane IDA
IDA: Inferred from direct assay
11060023 RGD
is active in synapse EXP
EXP: Inferred from Experiment
21797867 RGD
is active in synapse IDA
IDA: Inferred from direct assay
15095872 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated proteins 1A/1B light chain 3A

  • MAP1 light chain 3-like protein 1

  • MAP1A/1B light chain 3 A

  • MAP1A/MAP1B LC3 A

  • MAP1A/MAP1B light chain 3 A

  • autophagy-related protein LC3 A

  • autophagy-related ubiquitin-like modifier LC3 A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08028 MAP1LC3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21273 Map1lc3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27792 Map1lc3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map1lc3a NCBI NCBI:84557