Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Also Known as Prmt4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363026

About Carm1

Primary_assembly 8: 20,097,254-20,147,689 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 8 phenotypes. Biased expression in Muscle (RPKM 111.1), Heart (RPKM 11.5) and 9 other tissues.

Summary

Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including negative regulation of dendrite development; regulation of mRNA binding activity; and response to cAMP. Located in cytoplasm and nucleus. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 Products (2)

mRNA Protein Name
NM_001034088.3 NP_001029260.1 histone-arginine methyltransferase CARM1 isoform b
NM_001030041.4 NP_001025212.1 histone-arginine methyltransferase CARM1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16330542 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
22736542 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16508003 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
16330542 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Carm1 Protein Structure

CARM1

CARM1: pfam11531 (34 - 138)

SmtA

SmtA: COG0500 (184 - 394)

AdoMet_MTases

AdoMet_MTases: cd02440 (188 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 608 a.a.
Protein Preferred Names Protein Names

histone-arginine methyltransferase CARM1

  • protein arginine N-methyltransferase 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-111109 EZM 2302 Inhibitor 99.51% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-100565 SGC2085 Inhibitor 99.46% Unkown
HY-12759 CARM1-IN-1 Inhibitor 95.0% Unkown
HY-21999 tert-Butyl 6-aminocaproate 99.96% Unkown
HY-156152A PROTAC CARM1 degrader-1 hydrochloride Degrader / Unkown
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.17% Unkown
HY-15214 CARM1-IN-3 Inhibitor 98.90% Unkown
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-163561 CARM1-IN-6 99.59% Unkown
HY-163561A CARM1-IN-6 dihydrochloride Inhibitor 98.44% Unkown
HY-RS01926 CARM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-136809 PRMT6-IN-2 Inhibitor / Unkown
HY-156152 PROTAC CARM1 degrader-1 Inhibitor / Unkown
HY-156153 PROTAC CARM1 degrader-2 Inhibitor / Unkown
HY-158157 ZL-28-6 Inhibitor / Unkown
HY-158158 CARM1-IN-5 Inhibitor / Unkown
HY-161334 CARM1-IN-4 / Unkown
HY-172368 PROTAC CARM1/IKZF3 degrader-1 / Unkown
HY-172369 CARM1/IKZF3 ligand 1 Inhibitor / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-183653 AK442 Inhibitor / Unkown
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114206 SKI-73 / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown
HY-172370 Thalidomide-NH-C4-Boc / Unkown
HY-W013500 (1-Nitroethene-1,2-diyl)dibenzene Inhibitor 99.05% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carm1 NCBI NCBI:10498