Cav2 - caveolin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363425

Summary

Enables mitogen-activated protein kinase kinase kinase binding activity; phosphoprotein binding activity; and syntaxin binding activity. Involved in several processes, including Insulin Receptor signaling pathway; negative regulation of endothelial cell proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including caveola; lipid droplet; and nuclear inner membrane. Part of protein-containing complex. Biomarker of high grade glioma and obesity. Human ortholog(s) of this gene implicated in low tension glaucoma and primary open angle glaucoma. Orthologous to human CAV2 (caveolin 2). [provided by Alliance of Genome Resources, Apr 2022]

Cav2 Products (1)

mRNA Protein Name
NM_131914.3 NP_571989.3 caveolin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNARE binding IDA
IDA: Inferred from direct assay
11883949 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
20455999 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
15781236 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12649076 RGD
enables syntaxin binding IDA
IDA: Inferred from direct assay
11883949 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
11883949 RGD
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
20455999 RGD
involved in negative regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
21807947 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
20455999 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
20455999 RGD
involved in positive regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
20455999 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
18162583 RGD
located in caveola IDA
IDA: Inferred from direct assay
16000875 RGD
located in cell surface IDA
IDA: Inferred from direct assay
12649076 RGD
located in lipid droplet IDA
IDA: Inferred from direct assay
14528016 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
18162583 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
20455999 RGD
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
20455999 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18162583 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12649076 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caveolin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (24)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1080A ω-Agatoxin IVA TFA Inhibitor 99.52% Unkown
HY-P1074 SNX-482 Inhibitor ≥99.0% Unkown
HY-119373 Cav 2.2 blocker 1 Inhibitor 98.85% Unkown
HY-120751 TROX-1 Inhibitor 99.55% Unkown
HY-164803 CBD3063 Modulator 99.75% Unkown
HY-P1080 ω-Agatoxin IVA Inhibitor 98.71% Unkown
HY-132268 Cav 2.2 blocker 2 Inhibitor 98.51% Unkown
HY-115597 BTT-266 Antagonist 98.90% Unkown
HY-120751A (S)-TROX-1 Inhibitor 99.52% Unkown
HY-115596 BTT-369 Antagonist / Unkown
HY-147639 Cav 2.2/3.2 blocker 1 Inhibitor / Unkown
HY-148866 Cavα2δ1&NET-IN-3 Inhibitor / Unkown
HY-169845 Calcium Channel antagonist 6 Antagonist / Unkown
HY-180400 PAM-2 / Unkown
HY-181612 COX-2/CaV2.2-IN-1 Inhibitor / Unkown
HY-181957 KB528 / Unkown
HY-P10898 GeX-2 / Unkown
HY-P5813 Cd1a Inhibitor / Unkown
HY-P5874 Myr-TAT-CBD3 Inhibitor / Unkown
HY-RS01987 CAV2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N12768 Rhodojaponin VI Inhibitor / Unkown
HY-P3269 Calciseptine Inhibitor / Unkown
HY-RS20256 Cav2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26764 Cav2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cav2 NCBI NCBI:858