TRABD2B - TraB domain containing 2B Gene

Also Known as TIKI2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 388630

About TRABD2B

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,760,528-47,997,385 (from NCBI)

This gene has 2 transcripts (splice variants), 113 orthologues and 1 paralogue. Broad expression in kidney (RPKM 3.6), gall bladder (RPKM 0.8) and 16 other tissues.

Summary

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TRABD2B Products (1)

mRNA Protein Name
NM_001194986.2 NP_001181915.1 metalloprotease TIKI2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IDA
IDA: Inferred from direct assay
22726442 GOA
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
22726442 GOA
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
22726442 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22726442 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
22726442 GOA
involved in positive regulation of protein oxidation IDA
IDA: Inferred from direct assay
22726442 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
22726442 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
22726442 GOA
Cellular Component GO Annotation Evidence References Source
located in organelle membrane IDA
IDA: Inferred from direct assay
22726442 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22726442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRABD2B Protein Structure

TraB

TraB: TraB family (50 - 349)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
Protein Preferred Names Protein Names

metalloprotease TIKI2

  • TRAB domain-containing protein 2B

TRABD2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
TRABD2B A6NFA1 Wnt3a Mus musculus P27467
Anti Tag CoIP
22726442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14965 TRABD2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRABD2B VGNC VGNC:84867
Macaca mulatta TRABD2B VGNC VGNC:100176
Mus musculus TRABD2B MGD MGI:3650152
Bos taurus TRABD2B VGNC VGNC:106996
Felis catus TRABD2B VGNC VGNC:80391
Rattus norvegicus TRABD2B RGD RGD:1586386
Others TRABD2B NCBI