LBP - lipopolysaccharide binding protein Gene

Also Known as BPIFD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3929

About LBP

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,346,482-38,377,013 (from NCBI)

This gene has 1 transcript (splice variant), 104 orthologues and 12 paralogues. Restricted expression toward liver (RPKM 139.3).

Summary

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative Bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

LBP Products (1)

mRNA	Protein	Name
NM_004139.5	NP_004130.2	lipopolysaccharide-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables coreceptor activity	IPI IPI: Inferred from physical interaction	15294986	GOA
enables lipopeptide binding	IDA IDA: Inferred from direct assay	15294986	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables lipopolysaccharide binding	IMP IMP: Inferred from mutant phenotype	24120359	GOA
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	12932360	GOA
involved in cell surface pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	15294986	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12594207	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24120359	GOA
acts upstream of or within cellular response to lipoteichoic acid	IDA IDA: Inferred from direct assay	12594207	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	11528597	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12932360	GOA
involved in detection of molecule of bacterial origin	IDA IDA: Inferred from direct assay	11528597	GOA
involved in lipopolysaccharide transport	IDA IDA: Inferred from direct assay	8985160	GOA
involved in lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	8409400	GOA
involved in macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	24120359	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	11739189	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	11528597	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12594207	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24120359	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	8409400	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	11528597	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	2402637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
lipopolysaccharide-binding protein	BPI fold containing family D, member 2

LBP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	LBP	P18428	PRDX4	Homo sapiens	Q13162	Y2H	21988832
Intra	LBP	P18428	PRDX4	Homo sapiens	Q13162	Confocal	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70313	LBP Protein, Human (HEK293, His)	P18428 (A26-V481)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78664	LBP Protein, Human (I465F, HEK293, His)	P18428 (A26-V481, I465F)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Alcoholic Hepatitis	Acute Alcoholic Hepatitis Acute Alcoholic Liver Disease Hepatitis, Alcoholic Hepatitis Alcoholic Ah - [Alcoholic Hepatitis] Ethanol Hepatitis
Toxic Pneumonitis	Acute Chemical Fume Pulmonary Edema Acute Chemical Pulmonary Edema Acute Pulmonary Edema Due To Fumes And/Or Vapors
Peritonitis	Retractile Mesenteritis Sclerosing Mesenteritis Acute Generalized Peritonitis Primary Bacterial Peritonitis Idiopathic Sclerosing Mesenteritis Mesenteric Panniculitis Peritoneal Retractile Mesenteritis Liposclerotic Mesenteritis Mesenteric Fibromatosis Mesenteric Lipodystrophy Mesenteric Lipogranuloma Fibromatosis, Abdominal Peritoneum Inflammation Peritonitis Of Undetermined Cause Peritonitis Of Unspecified Cause Pelviperitonitis Pelvic Peritonitis, Nos Generalised Peritonitis Nos Abdominal Peritonitis Acute Idiopathic Peritonitis Acute Lesser Sac Peritonitis Acute Peritoneal Inflammation Diffuse Peritonitis Peritoneal Inflammation Acute Primary Peritonitis Pneumococcal Peritonitis
Reactive Arthritis	Postdysenteric Arthropathy Reiter Disease Pira Reiter Syndrome Reiters Syndrome Arthritis, Reactive Fiessinger Leroy Reiter Syndrome Post-Bacterial Arthropathy Reiter'S Disease Post-Infectious Arthritis Post-Infectious Reactive Arthropathy Reiter'S Syndrome Arthritis Urethritica Fiessinger-Leroy Disease Polyarthritis Enterica Venereal Arthritis Arthritis Reactive Post-Dysenteric Arthropathy Arthritis, Venereal
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Toxic Shock Syndrome	Septic Shock Toxic Shock Tss Shock, Septic Staphylococcal Toxic Shock Syndrome Tss - [Toxic Shock Syndrome]
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Endocarditis
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Leptospirosis	Fort Bragg Fever Weil Disease Leptospirosis Icterohaemorrhagica Nanukayami Fever Canicola Fever Hemorrhagic Jaundice Mud Fever Stuttgart Disease Swamp Fever Rat Catcher'S Yellows Spirochetal Jaundice Weil'S Disease Cane-Cutter Fever Icterohemorrhagic Fever Rice-Field Fever Swineherd'S Disease Weil Syndrome Nanukayami Canine Leptospirosis Equine Infectious Anemia Leptospirosis Canicola Fever Due To Leptospira Autumnalis Gikiyami Leptospira Interrogans Autumnalis Infection Leptospira Interrogans Canicola Infection Leptospira Interrogans Hebdomadis Infection Leptospira Interrogans Pomona Infection Nanukayami Disease Pretibial Fever Seven-Day Fever Eia - [Equine Infectious Anaemia] Leptospira Interrogans Infection
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Filariasis	Disease Due To Superfamily Filarioidea Bancroftian Filarial Fever Mumu Wanganga Bancroftian Filariasis Wuchereriosis Brugiosis Malayan Filariasis
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Bacteremia 2	Bacteremia Bacteremia, Susceptibility To, 2 BACTS2 Bacteremia, Susceptibility To Bacteremia, Susceptibility To, Type 2
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141882	DC-LC3in-D5	Inhibitor	98.62%	Unkown
HY-172476	DSPE-PEG2000-YIGSR		95.0%	Unkown
HY-106010	LBP1	Agonist	/	Unkown
HY-155437	NEt-iFQ	Agonist	/	Unkown
HY-172475	DSPE-PEG1000-YIGSR		/	Unkown
HY-172476A	DSPE-PEG3400-YIGSR		/	Unkown
HY-172477	DSPE-PEG5000-YIGSR		/	Unkown
HY-P11772	LBP-14		/	Unkown
HY-P11772A	LBP-14-NH2 TFA	Inhibitor	98.61%	Unkown
HY-RS04226	EHHADH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07543	LBP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07544	Lbp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12272	RPSA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16804	Lbp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18562	Ehhadh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25044	Ehhadh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LBP	RGD	RGD:61865
Mus musculus	LBP	MGD	MGI:1098776
Bos taurus	LBP	VGNC	VGNC:56192
Macaca mulatta	LBP	VGNC	VGNC:74240
Others	LBP	NCBI