Map4k5 - mitogen-activated protein kinase kinase kinase kinase 5 Gene

Also Known as KHS; GCKR; MAPKKKK5; 4432415E19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 399510

About Map4k5

Chromosome 12: 69,850,524-69,939,974 reverse strand.GRCm39:CM001005.3

This gene has 10 transcripts (splice variants), 200 orthologues, 35 paralogues and is associated with 14 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 9.4), bladder adult (RPKM 8.2) and 28 other tissues.

Summary

Predicted to enable ATP binding activity and MAP kinase kinase kinase kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Is expressed in metanephros and testis. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Map4k5 Products (1)

mRNA Protein Name
NM_201519.2 NP_958927.2 mitogen-activated protein kinase kinase kinase kinase 5

Map4k5 Protein Structure

STKc_MAP4K5

STKc_MAP4K5: cd06646 (9 - 276)

CNH

CNH: smart00036 (511 - 826)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 5

  • MAPK/ERK kinase kinase kinase 5

  • MEK kinase kinase 5

  • MEKKK 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-179111 HPK1-IN-64 Inhibitor / Unkown
HY-E70839 KHS1 Recombinant Human Active Protein Kinase / Unkown
HY-RS08083 MAP4K5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08084 Map4k5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08085 Map4k5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k5 NCBI NCBI:11183