CCL3L3 - C-C motif chemokine ligand 3 like 3 Gene

Also Known as LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 414062

About CCL3L3

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:36,194,869-36,196,758 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 185 orthologues, 25 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 50.8), brain (RPKM 6.1) and 4 other tissues.

Summary

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]

CCL3L3 Products (1)

mRNA	Protein	Name
NM_001001437.4	NP_001001437.2	C-C motif chemokine 3-like 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL3L3 Protein Structure

IL8

0
93 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 3-like 1	G0/G1 switch regulatory protein 19-2

CCL3L3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCL3L1	P16619	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	CCL3L1	P16619	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	CCL3L1	P16619	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	CCL3L1	P16619	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	CCL3L1	P16619	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	CCL3L1	P16619	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	CCL3L1	P16619	SLC41A3	Homo sapiens	Q96GZ6	Validated Y2H	32296183
Intra	CCL3L1	P16619	SLC41A3	Homo sapiens	Q96GZ6	Y2H Array	32296183
Intra	CCL3L1	P16619	SLC41A3	Homo sapiens	Q96GZ6	Y2H Prey Pooling	32296183
Intra	CCL3L1	P16619	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CCL3L1	P16619	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	CCL3L1	P16619	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL3L3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7231	LD78-beta/CCL3L1 Protein, Human	P16619 (A24-A93)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7769	LD78-beta/CCL3L1 Protein, Human (HEK293 His)	P16619 (A24-A93)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Fraser Syndrome 1	Fraser Syndrome Cryptophthalmos With Other Malformations Cryptophthalmos Syndrome FRASRS1 Cryptophthalmos-Syndactyly Syndrome Fraser-Francois Syndrome Cyclopism Meyer-Schwickerath'S Syndrome Ulrich-Feichtiger Syndrome Cryptophthalmos Syndactyly Syndrome Fraser'S Syndrome Meyer-Schwickerath Syndrome Ullrich-Feichtiger Syndrome
Asymptomatic Dengue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124668	CCR1 antagonist 12	Antagonist	/	Unkown
HY-RS02101	CCL3L3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCL3L3	MGD	MGI:98260