Smyd3 - SET and MYND domain containing 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 498295

About Smyd3

Primary_assembly 13: 90,709,270-91,266,253 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 231 orthologues, 5 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 59.6), Kidney (RPKM 4.4) and 9 other tissues.

Summary

Predicted to enable RNA polymerase II complex binding activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and histone-lysine N-methyltransferase activity. Predicted to act upstream of or within several processes, including cellular response to dexamethasone stimulus; nucleosome assembly; and regulation of protein phosphorylation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human SMYD3 (SET and MYND domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Smyd3 Products (1)

mRNA	Protein	Name
NM_001025762.1	NP_001020933.1	histone-lysine N-methyltransferase SMYD3

Smyd3 Protein Structure

SET_SMYD3

zf-MYND

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase SMYD3	SET and MYND domain-containing protein 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19324	EPZ031686	Inhibitor	99.71%	Unkown
HY-21972	BCI-121	Inhibitor	99.89%	Unkown
HY-141877	MS4322	Degrader	99.14%	Unkown
HY-112080	BAY-6035	Inhibitor	99.51%	Unkown
HY-151379	EM127	Inhibitor	99.94%	Unkown
HY-104009A	GSK2807 Trifluoroacetate	Inhibitor	99.83%	Unkown
HY-128352	SMYD3-IN-1	Inhibitor	98.03%	Unkown
HY-141877B	MS4322 (isomer)		99.87%	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152228	SMYD3-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smyd3	NCBI	NCBI:64754