Magi2 - membrane associated guanylate kinase, WW and PDZ domain containing 2 Gene

Also Known as AIP-1; Acvri1; Magi-2; S-SCAM; Acvrip1; Acvrinp1; mKIAA0705

Species: Mus musculus

Gene Type: protein coding

Gene ID: 50791

Summary

Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in cytoplasm; dendrite; and plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Used to study schizophrenia. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Magi2 Products (3)

mRNA	Protein	Name
NM_001170745.1	NP_001164216.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3
NM_001170746.1	NP_001164217.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1
NM_015823.3	NP_056638.1	membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	10681527	MGI
enables activin receptor binding	IPI IPI: Inferred from physical interaction	10681527	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14529612	MGI
enables type II activin receptor binding	IPI IPI: Inferred from physical interaction	16648306	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	10681527	MGI
involved in clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	24608321	MGI
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	10681527	MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	20534458	MGI
involved in positive regulation of synaptic vesicle clustering	IDA IDA: Inferred from direct assay	20534458	MGI
acts upstream of or within signal transduction	IPI IPI: Inferred from physical interaction	10681527	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	24608321	MGI
located in ciliary base	IDA IDA: Inferred from direct assay	24608321	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16870733	MGI
located in dendrite	IDA IDA: Inferred from direct assay	20534458	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	24608321	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	24608321	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16870733	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	activin receptor interacting protein 1 atrophin-1-interacting protein 1 membrane-associated guanylate kinase inverted 2

Magi2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Magi2	Q9WVQ1	Dll1	Mus musculus	Q61483	Y2H	14529612

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07982	MAGI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22622	Magi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Magi2	NCBI	NCBI:9863