PLAC8 - placenta associated 8 Gene

Also Known as C15; DGIC; onzin; PNAS-144

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51316

About PLAC8

Cytogenetic location: 4q21.22 Genomic coordinates (GRCh38): 4:83,090,048-83,114,729 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 48.1), colon (RPKM 47.5) and 10 other tissues.

Summary

Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including brown fat cell differentiation; defense response to bacterium; and response to cold. Predicted to be located in azurophil granule lumen and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PLAC8 Products (3)

mRNA Protein Name
NM_001130715.2 NP_001124187.1 placenta-specific gene 8 protein
NM_001130716.2 NP_001124188.1 placenta-specific gene 8 protein
NM_016619.3 NP_057703.1 placenta-specific gene 8 protein

PLAC8 Protein Structure

PLAC8

PLAC8: PLAC8 family (26 - 105)

  • 0
  • 100
  • 115 a.a.
Protein Preferred Names Protein Names

placenta-specific gene 8 protein

  • down-regulated in gastrointestinal cancer protein

Related Diseases

Diseases Alias
Hypoglycemia, Leucine-Induced

  • Leucine-Sensitive Hypoglycemia Of Infancy

  • Leucine-Induced Hypoglycemia

  • LIH

  • Hypoglycemia Of Infancy, Leucine-Sensitive

  • Familial Infantile Hypoglycemia Precipitated By Leucine

  • Hypoglycemia Leucine Induced

  • Hypoglycemia Leucine-Induced
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10641 PLAC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19731 Plac8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26227 Plac8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLAC8 VGNC VGNC:56782
Mus musculus PLAC8 MGD MGI:2445289
Rattus norvegicus PLAC8 RGD RGD:1308102
Canis familiaris PLAC8 VGNC VGNC:44636
Macaca mulatta PLAC8 VGNC VGNC:76072
Felis catus PLAC8 VGNC VGNC:79364
Others PLAC8 NCBI