PGM5 - phosphoglucomutase 5 Gene

Also Known as PGMRP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5239

About PGM5

Cytogenetic location: 9q21.11 Genomic coordinates (GRCh38): 9:68,356,611-68,531,061 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 6 paralogues. Broad expression in prostate (RPKM 50.4), esophagus (RPKM 35.1) and 15 other tissues.

Summary

Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008]

PGM5 Products (1)

mRNA Protein Name
NM_021965.4 NP_068800.2 phosphoglucomutase-like protein 5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables phosphoglucomutase activity IDA
IDA: Inferred from direct assay
8175905 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
8175905 GOA
located in costamere IDA
IDA: Inferred from direct assay
8175905 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10867799 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
8175905 GOA
located in intercalated disc IDA
IDA: Inferred from direct assay
8175905 GOA
located in sarcolemma IDA
IDA: Inferred from direct assay
10867799 GOA
located in spot adherens junction IDA
IDA: Inferred from direct assay
8175905 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
8175905 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGM5 Protein Structure

PGM_PMM_I

PGM_PMM_I: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I (23 - 162)

PGM_PMM_II

PGM_PMM_II: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (218 - 305)

PGM_PMM_III

PGM_PMM_III: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III (312 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 567 a.a.
Protein Preferred Names Protein Names

phosphoglucomutase-like protein 5

  • PGM-RP

Related Diseases

Diseases Alias
Noonan Syndrome 10

  • NS10

  • Noonan Syndrome, Type 10
Breast Angiosarcoma

  • Angiosarcoma Of The Breast

  • Hemangiosarcoma Of The Breast

  • Primary Angiosarcoma Of Breast
Myopathy, Myofibrillar, 5

  • Myofibrillar Myopathy 5

  • MFM5

  • Myopathy, Myofibrillar, Filamin C-Related

  • Filaminopathy, Autosomal Dominant

  • Filaminopathy

  • Muscle Filaminopathy

  • Autosomal Dominant Filaminopathy

  • Mfm Filamin C-Related

  • Myopathy Myofibrillar Filamin C-Related

  • Myopathy, Myofibrillar, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10393 PGM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21407 Pgm5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27926 Pgm5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PGM5 VGNC VGNC:68820
Rattus norvegicus PGM5 RGD RGD:1307969
Mus musculus PGM5 MGD MGI:1925668
Canis familiaris PGM5 VGNC VGNC:49942
Macaca mulatta PGM5 VGNC VGNC:75971
Bos taurus PGM5 VGNC VGNC:32797
Others PGM5 NCBI