PIGR - polymeric immunoglobulin receptor Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5284

About PIGR

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,928,522-206,946,466 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues.

Summary

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

PIGR Products (1)

mRNA	Protein	Name
NM_002644.4	NP_002635.2	polymeric immunoglobulin receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables polymeric immunoglobulin binding	IDA IDA: Inferred from direct assay	32029689	GOA
enables polymeric immunoglobulin receptor activity	IDA IDA: Inferred from direct assay	22022593	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Fc receptor signaling pathway	IDA IDA: Inferred from direct assay	22022593	GOA
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: Inferred from direct assay	24248522	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	22022593	GOA
involved in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IDA IDA: Inferred from direct assay	9379029	GOA
involved in receptor clustering	IDA IDA: Inferred from direct assay	22022593	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	24248522	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9379029	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
part of secretory IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	32029686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIGR Protein Structure

V-set

0
200
400
600
764 a.a.

Protein Preferred Names	Protein Names
polymeric immunoglobulin receptor	hepatocellular carcinoma associated protein TB6

Recombinant PIGR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71065	PIGR Protein, Human (G365S, HEK293, His)	P01833/NP_002635.2 (K19-R638, G365S)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Immunoglobulin Alpha Deficiency	Iga Deficiency Gamma-A-Globulin Deficiency Immunoglobulin A Deficiency
Periampullary Adenocarcinoma
Alcoholic Gastritis	Alcoholic Gastritis, With Hemorrhage Alcoholic Gastritis, Without Mention Of Hemorrhage Alcohol Gastritis Etoh Gastritis
Atrophy Of Prostate
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10500	PIGR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-E70426	Polyphosphate kinase		/	Unkown
HY-E70426A	Polyphosphate Kinase, Propionibacterium shermanii		/	Unkown
HY-RS18254	Pigr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24734	Pigr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIGR	VGNC	VGNC:75991
Bos taurus	PIGR	VGNC	VGNC:32876
Canis familiaris	PIGR	VGNC	VGNC:44540
Rattus norvegicus	PIGR	RGD	RGD:3328
Mus musculus	PIGR	MGD	MGI:103080
Felis catus	PIGR	VGNC	VGNC:68848
Others	PIGR	NCBI