PIGR - polymeric immunoglobulin receptor Gene

Homo sapiens

Gene ID: 5284 | Gene type: protein coding

About PIGR

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,928,522-206,946,466 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues.

Summary

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

PIGR Products(1)

mRNA	Protein	Name
NM_002644.4	NP_002635.2	polymeric immunoglobulin receptor precursor

PIGR Protein Structure

V-set

0
200
400
600
764 a.a.

Protein Preferred Names

Protein Names

polymeric immunoglobulin receptor

hepatocellular carcinoma associated protein TB6

Recombinant PIGR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71065	PIGR Protein, Human (HEK293, His)	P01833 (K19-R638)	≥95%
HY-P73377	PIGR Protein, Human (G365S, HEK293, His)	P01833 (M1-R638, G365S)	≥95%

Related Diseases

Diseases

Alias

Protein-Energy Malnutrition

PEM	Protein Energy Malnutrition

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Periampullary Adenocarcinoma

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Atrophy Of Prostate

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10500	PIGR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIGR	VGNC	VGNC:75991
Bos taurus	PIGR	VGNC	VGNC:32876
Canis familiaris	PIGR	VGNC	VGNC:44540
Rattus norvegicus	PIGR	RGD	RGD:3328
Mus musculus	PIGR	MGD	MGI:103080
Felis catus	PIGR	VGNC	VGNC:68848
Macaca fascicularis	PIGR	NCBI
Others	PIGR	NCBI