PLCB2 - phospholipase C beta 2 Gene

Also Known as PLC-beta-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5330

About PLCB2

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,284,256-40,307,935 (from NCBI)

This gene has 15 transcripts (splice variants), 219 orthologues and 14 paralogues. Broad expression in spleen (RPKM 26.9), bone marrow (RPKM 19.8) and 17 other tissues.

Summary

The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 Taste Receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017]

PLCB2 Products (4)

mRNA	Protein	Name
NM_001284297.2	NP_001271226.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2
NM_001284298.2	NP_001271227.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3
NM_001284299.2	NP_001271228.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4
NM_004573.3	NP_004564.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatidylinositol phospholipase C activity	IDA IDA: Inferred from direct assay	9188725	GOA
enables phosphatidylinositol phospholipase C activity	IMP IMP: Inferred from mutant phenotype	8519600	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21115837	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in phosphatidylinositol metabolic process	IDA IDA: Inferred from direct assay	9188725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLCB2 Protein Structure

EF-hand_like

PI-PLC-X

PI-PLC-Y

C2

PLC-beta_C

0
200
400
600
800
1000
1185 a.a.

Protein Preferred Names	Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2	phosphoinositide phospholipase C-beta-2

Related Diseases

Diseases	Alias
Prostate Leiomyosarcoma	Leiomyosarcoma Of The Prostate
Night Blindness, Congenital Stationary, Type 1h	Congenital Stationary Night Blindness 1h CSNB1H Congenital Stationary Night Blindness Type 1h Night Blindness, Congenital Stationary, 1h
Neurogenic Bowel

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10653	PLCB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22731	Plcb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29245	Plcb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLCB2	MGD	MGI:107465
Rattus norvegicus	PLCB2	RGD	RGD:621004
Canis familiaris	PLCB2	VGNC	VGNC:44645
Bos taurus	PLCB2	VGNC	VGNC:32981
Macaca mulatta	PLCB2	VGNC	VGNC:76164
Felis catus	PLCB2	VGNC	VGNC:80881