Prdx4 - peroxiredoxin 4 Gene

Also Known as Prx4; TRANK; AOE372; Prx-iv

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53381

Summary

Enables identical protein binding activity. Acts upstream of or within several processes, including cell redox homeostasis; negative regulation of male germ cell proliferation; and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Located in cytosol and endoplasmic reticulum. Is expressed in dorsal root ganglion; embryo; future spinal cord; and spinal cord. Orthologous to human PRDX4 (peroxiredoxin 4). [provided by Alliance of Genome Resources, Apr 2022]

Prdx4 Products (2)

mRNA Protein Name
NM_001313711.1 NP_001300640.1 peroxiredoxin-4 isoform 1 precursor
NM_016764.5 NP_058044.1 peroxiredoxin-4 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21835919 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24462249 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell redox homeostasis IGI
IGI: Inferred from genetic interaction
23589496 MGI
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
22981861 MGI
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
19105792 MGI
acts upstream of or within negative regulation of male germ cell proliferation IMP
IMP: Inferred from mutant phenotype
19105792 MGI
acts upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline IGI
IGI: Inferred from genetic interaction
22981861 MGI
acts upstream of or within protein maturation by protein folding IGI
IGI: Inferred from genetic interaction
22981861 MGI
acts upstream of or within reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
11229364 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
19105792 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
19105792 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11229364 MGI
located in cytosol IDA
IDA: Inferred from direct assay
21835919 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21835919 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peroxiredoxin-4

  • Prx IV

  • antioxidant enzyme AOE372

  • peroxiredoxin IV

  • thioredoxin peroxidase AO372

  • thioredoxin-dependent peroxide reductase A0372

  • thioredoxin-dependent peroxiredoxin 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18834 Prdx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11077 PRDX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25326 Prdx4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdx4 NCBI NCBI:10549