Ppm1d - protein phosphatase 1D magnesium-dependent, delta isoform Gene

Also Known as Wip1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53892

Summary

Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine Phosphatase activity. Involved in DNA methylation and heterochromatin assembly. Acts upstream of or within DNA damage response, signal transduction by p53 class mediator; G2/M transition of mitotic cell cycle; and response to bacterium. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in breast Cancer. Orthologous to human PPM1D (protein Phosphatase, Mg2+/Mn2+ dependent 1D). [provided by Alliance of Genome Resources, Apr 2022]

Ppm1d Products (1)

mRNA Protein Name
NM_016910.3 NP_058606.3 protein phosphatase 1D

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response, signal transduction by p53 class mediator IDA
IDA: Inferred from direct assay
21522133 MGI
involved in DNA methylation-dependent heterochromatin formation IDA
IDA: Inferred from direct assay
24135283 MGI
acts upstream of or within G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
11809801 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
11809801 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein phosphatase 1D

  • PP2C-delta

  • p53-induced protein phosphatase 1

  • protein phosphatase magnesium-dependent 1 delta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15880 CCT007093 98.34% Unkown
HY-172609 SL-176 99.91% Unkown
HY-173084 BRD6257 / Unkown
HY-RS10962 PPM1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17556 Ppm1d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24014 Ppm1d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppm1d NCBI NCBI:8493