PCBP3 - poly(rC) binding protein 3 Gene

Also Known as PCBP3OT; ALPHA-CP3; PCBP3-OT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54039

About PCBP3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:45,643,725-45,942,450 (from NCBI)

This gene has 22 transcripts (splice variants), 164 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues.

Summary

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in Other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

PCBP3 Products (23)

mRNA Protein Name
NM_001130141.2 NP_001123613.1 poly(rC)-binding protein 3 isoform 2
NM_001348238.2 NP_001335167.1 poly(rC)-binding protein 3 isoform 3
NM_001348239.2 NP_001335168.1 poly(rC)-binding protein 3 isoform 4
NM_001348240.2 NP_001335169.1 poly(rC)-binding protein 3 isoform 5
NM_001348241.2 NP_001335170.1 poly(rC)-binding protein 3 isoform 6
NM_001348242.2 NP_001335171.1 poly(rC)-binding protein 3 isoform 7
NM_001348243.2 NP_001335172.1 poly(rC)-binding protein 3 isoform 8
NM_001348244.2 NP_001335173.1 poly(rC)-binding protein 3 isoform 9
NM_001348245.2 NP_001335174.1 poly(rC)-binding protein 3 isoform 10
NM_001382276.1 NP_001369205.1 poly(rC)-binding protein 3 isoform 7
NM_001382277.1 NP_001369206.1 poly(rC)-binding protein 3 isoform 1
NM_001382278.1 NP_001369207.1 poly(rC)-binding protein 3 isoform 3
NM_001382279.1 NP_001369208.1 poly(rC)-binding protein 3 isoform 5
NM_001382281.1 NP_001369210.1 poly(rC)-binding protein 3 isoform 1
NM_001382282.1 NP_001369211.1 poly(rC)-binding protein 3 isoform 1
NM_001382283.1 NP_001369212.1 poly(rC)-binding protein 3 isoform 1
NM_001382284.1 NP_001369213.1 poly(rC)-binding protein 3 isoform 1
NM_001382285.1 NP_001369214.1 poly(rC)-binding protein 3 isoform 1
NM_001382286.1 NP_001369215.1 poly(rC)-binding protein 3 isoform 1
NM_001382287.1 NP_001369216.1 poly(rC)-binding protein 3 isoform 1
NM_001382288.1 NP_001369217.1 poly(rC)-binding protein 3 isoform 1
NM_001384156.1 NP_001371085.1 poly(rC)-binding protein 3 isoform 1
NM_020528.3 NP_065389.2 poly(rC)-binding protein 3 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCBP3 Protein Structure

KH_1

KH_1: KH domain (47 - 107)

KH_1

KH_1: KH domain (131 - 194)

KH_1

KH_1: KH domain (296 - 357)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

poly(rC)-binding protein 3

  • PCBP3 overlapping transcript 1

Related Diseases

Diseases Alias
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10117 PCBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18676 Pcbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25162 Pcbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCBP3 RGD RGD:1307430
Bos taurus PCBP3 VGNC VGNC:53597
Canis familiaris PCBP3 VGNC VGNC:53035
Macaca mulatta PCBP3 VGNC VGNC:81735
Felis catus PCBP3 VGNC VGNC:102800
Mus musculus PCBP3 MGD MGI:1890470
Others PCBP3 NCBI