2. Gene
  3. PCBP3 - poly(rC) binding protein 3 Gene

PCBP3 - poly(rC) binding protein 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PCBP3OT; ALPHA-CP3; PCBP3-OT1

Gene ID: 54039 | Gene type: protein coding

About PCBP3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:45,643,725-45,942,450 (from NCBI)

This gene has 22 transcripts (splice variants), 164 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.3), endometrium (RPKM 4.4) and 17 other tissues.

Summary

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

PCBP3 Products(23)

mRNA Protein Name
NM_001130141.2 NP_001123613.1 poly(rC)-binding protein 3 isoform 2
NM_001348238.2 NP_001335167.1 poly(rC)-binding protein 3 isoform 3
NM_001348239.2 NP_001335168.1 poly(rC)-binding protein 3 isoform 4
NM_001348240.2 NP_001335169.1 poly(rC)-binding protein 3 isoform 5
NM_001348241.2 NP_001335170.1 poly(rC)-binding protein 3 isoform 6
NM_001348242.2 NP_001335171.1 poly(rC)-binding protein 3 isoform 7
NM_001348243.2 NP_001335172.1 poly(rC)-binding protein 3 isoform 8
NM_001348244.2 NP_001335173.1 poly(rC)-binding protein 3 isoform 9
NM_001348245.2 NP_001335174.1 poly(rC)-binding protein 3 isoform 10
NM_001382276.1 NP_001369205.1 poly(rC)-binding protein 3 isoform 7
NM_001382277.1 NP_001369206.1 poly(rC)-binding protein 3 isoform 1
NM_001382278.1 NP_001369207.1 poly(rC)-binding protein 3 isoform 3
NM_001382279.1 NP_001369208.1 poly(rC)-binding protein 3 isoform 5
NM_001382281.1 NP_001369210.1 poly(rC)-binding protein 3 isoform 1
NM_001382282.1 NP_001369211.1 poly(rC)-binding protein 3 isoform 1
NM_001382283.1 NP_001369212.1 poly(rC)-binding protein 3 isoform 1
NM_001382284.1 NP_001369213.1 poly(rC)-binding protein 3 isoform 1
NM_001382285.1 NP_001369214.1 poly(rC)-binding protein 3 isoform 1
NM_001382286.1 NP_001369215.1 poly(rC)-binding protein 3 isoform 1
NM_001382287.1 NP_001369216.1 poly(rC)-binding protein 3 isoform 1
NM_001382288.1 NP_001369217.1 poly(rC)-binding protein 3 isoform 1
NM_001384156.1 NP_001371085.1 poly(rC)-binding protein 3 isoform 1
NM_020528.3 NP_065389.2 poly(rC)-binding protein 3 isoform 1

PCBP3 Protein Structure

KH_1

KH_1: KH domain (47 - 107)

KH_1

KH_1: KH domain (131 - 194)

KH_1

KH_1: KH domain (296 - 357)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

poly(rC)-binding protein 3

PCBP3 overlapping transcript 1

Related Diseases

Diseases Alias
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10117 PCBP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCBP3 RGD RGD:1307430
Bos taurus PCBP3 VGNC VGNC:53597
Canis familiaris PCBP3 VGNC VGNC:53035
Macaca mulatta PCBP3 VGNC VGNC:81735
Felis catus PCBP3 VGNC VGNC:102800
Mus musculus PCBP3 MGD MGI:1890470
Macaca fascicularis PCBP3 NCBI
Others PCBP3 NCBI