PODXL - podocalyxin like Gene

Also Known as PC; PDX; PCLP; Gp200; gp135; PCLP-1; PODXL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5420

About PODXL

Cytogenetic location: 7q32.3 Genomic coordinates (GRCh38): 7:131,500,271-131,556,628 (from NCBI)

This gene has 8 transcripts (splice variants), 160 orthologues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 88.8), lung (RPKM 31.4) and 19 other tissues.

Summary

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

PODXL Products (2)

mRNA	Protein	Name
NM_001018111.3	NP_001018121.1	podocalyxin isoform 1 precursor
NM_005397.4	NP_005388.2	podocalyxin isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22662192	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	18456258	GOA
involved in positive regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	18456258	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18456258	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	15326289	GOA
located in filopodium	IDA IDA: Inferred from direct assay	18456258	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	18456258	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18456258	GOA
located in ruffle	IDA IDA: Inferred from direct assay	18456258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PODXL Protein Structure

CD34_antigen

0
100
200
300
400
500
558 a.a.

Protein Preferred Names	Protein Names
podocalyxin	GCTM-2 antigen

PODXL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PODXL	O00592	NHERF2	Homo sapiens	Q15599	Anti Tag CoIP	35271311
Intra	PODXL	O00592	IQGAP1	Homo sapiens	P46940	Confocal	22662192
Intra	PODXL	O00592	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	22662192

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PODXL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71814	PODXL Protein, Human (P.pastoris, His)	O00592-1 (Q32-F458)	≥ 90%, as determined by reducing SDS-PAGE.

PODXL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81355	PODXL Antibody (YA1100)	IHC-P	Human
HY-P81355A	PODXL Antibody (YA1100)(PBS only)	IHC-P	Human
HY-P83797	PODXL Antibody (YA3494)	IHC-P, FC, ELISA	Human
HY-P83797A	PODXL Antibody (YA3494)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85331	PODXL Antibody (YA5023)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human

Related Diseases

Diseases	Alias
Atypical Juvenile Parkinsonism
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Parkin Type Of Early-Onset Parkinson Disease	Park-Parkin Prkn Parkinson Disease
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Periampullary Adenocarcinoma
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Ampulla Of Vater Cancer	Ampulla Of Vater Carcinoma Ampullary Carcinoma Malignant Tumour Of Ampulla Of Vater Carcinoma Of Ampulla Of Vater Carcinoma Of The Ampulla Of Vater Ampulloma
Nephrotic Syndrome, Type 10	NPHS10 Nephrotic Syndrome Type 10 Idiopathic Steroid-Sensitive Nephrotic Syndrome Nephrotic Syndrome 10
Familial Nephrotic Syndrome	Congenital Nephrotic Syndrome Nephrosis, Congenital Finnish Congenital Nephrotic Syndrome
Lipoid Nephrosis	Minimal Change Disease Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome Idiopathic Minimal Change Nephrotic Syndrome Mcns Minimal Change Glomerulopathy Minimal Change Nephrotic Syndrome Nephrotic Syndrome Minimal Change Nephrosis, Lipoid Glomerulonephritis, Minimal Change Nephrotic Syndrome, Minimal Change
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Crescentic Glomerulonephritis	Idiopathic Crescentic Glomerulonephritis
Acute Proliferative Glomerulonephritis	Acute Glomerulonephritis With Lesion Of Proliferative Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Ampulla Of Vater Adenocarcinoma	Adenocarcinoma Of Ampulla Of Vater Ampullary Adenocarcinoma
Nonaka Myopathy	Gne Myopathy Hibm Distal Myopathy With Rimmed Vacuoles Hereditary Inclusion Body Myopathy Ibm2 Inclusion Body Myopathy, Quadriceps-Sparing Qsm Dmrv Distal Myopathy, Nonaka Type Inclusion Body Myopathy 2 Inclusion Body Myopathy, Autosomal Recessive NM Nonaka Distal Myopathy Myopathy, Distal, With Or Without Rimmed Vacuoles Inclusion Body Myopathy, Hereditary, Autosomal Recessive Inclusion Body Myopathy Type 2 Quadriceps-Sparing Myopathy Quadriceps Sparing Myopathy Rimmed Vacuole Myopathy Inclusion Body Myopathy 2, Autosomal Recessive, Formerly Ibm2, Formerly Hibm2 Hereditary Inclusion Body Myopathy Type 2 Inclusion Body Myopathy 2, Autosomal Recessive Myopathy, Distal, With Rimmed Vacuoles Inclusion Body Myopathy Autosomal Recessive Myopathy, Inclusion Body, Type 2 Myopathy, Nonaka
Denys-Drash Syndrome	Drash Syndrome DDS Nephropathy, Wilms Tumor, And Genital Anomalies Wilms Tumor And Pseudohermaphroditism Wilms Tumor And Pseudo- Or True Hermaphroditism Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor Wilms Tumor-Dsd Syndrome Wilms Tumor-Disorder Of Sex Development Syndrome
Kidney Hypertrophy	Hypertrophy Of Kidney
Frasier Syndrome	FS
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10808	PODXL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10809	PODXL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19229	Podxl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20582	Podxl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25718	Podxl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27090	Podxl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992402	MAI1738	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PODXL	VGNC	VGNC:80660
Mus musculus	PODXL	MGD	MGI:1351317
Canis familiaris	PODXL	VGNC	VGNC:54792
Bos taurus	PODXL	VGNC	VGNC:53665
Rattus norvegicus	PODXL	RGD	RGD:621878
Macaca mulatta	PODXL	VGNC	VGNC:76201
Others	PODXL	NCBI