Apob - apolipoprotein B Gene

Also Known as Aa1064; Ac1-060; ApoB-48; ApoB-100; Apo B-100

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 54225

Summary

This gene product is the main Apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-L and apoB-H. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the rat apoBL isoform is also found in rat liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-L protein is produced after RNA editing of the apoB-H transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]

Apob Products (1)

mRNA Protein Name
NM_019287.2 NP_062160.2 apolipoprotein B-100 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11830580 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to prostaglandin stimulus IEP
IEP: Inferred from expression pattern
16545597 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
17405916 RGD
involved in response to carbohydrate IDA
IDA: Inferred from direct assay
16672736 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9402089 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16719989 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
16581047 RGD
involved in triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
9290048 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16227197 RGD
part of high-density lipoprotein particle IDA
IDA: Inferred from direct assay
12091487 RGD
part of low-density lipoprotein particle IDA
IDA: Inferred from direct assay
2429674 RGD
part of very-low-density lipoprotein particle IDA
IDA: Inferred from direct assay
12091487 RGD
located in vesicle lumen IDA
IDA: Inferred from direct assay
12091487 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apolipoprotein B-100

  • apolipoprotein B (including Ag(x) antigen)

  • apolipoprotein B PI

  • apolipoprotein B-48

Apob Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Apob Q7TMA5 Apoa1 Rattus norvegicus P04639
Comigration in SDS
18391222
Intra
Apob Q7TMA5 Apoa1 Rattus norvegicus P04639
Anti Bait CoIP
18391222
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148647 Mipomersen Inhibitor 96.88% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-108764 Mipomersen sodium Inhibitor 95.60% Phase 3
HY-18778 Obicetrapib Inhibitor 99.93% Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179364 PLTP-IN-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apob NCBI NCBI:338