Dll4 - delta like canonical Notch ligand 4 Gene

Also Known as Delta4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54485

Summary

Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2022]

Dll4 Products (1)

mRNA Protein Name
NM_019454.3 NP_062327.2 delta-like protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Notch binding IDA
IDA: Inferred from direct assay
10837024 MGI
enables Notch binding IPI
IPI: Inferred from physical interaction
20947685 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16000382 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
24667410 MGI
involved in Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in T cell differentiation IDA
IDA: Inferred from direct assay
15146182 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
15466160 MGI
involved in blood vessel lumenization IMP
IMP: Inferred from mutant phenotype
15466160 MGI
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
15466160 MGI
involved in branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in cardiac atrium morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in cardiac ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in dorsal aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in negative regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
26114479 MGI
acts upstream of or within negative regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
18559979 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in pericardium morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
26114479 MGI
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
22323600 MGI
involved in regulation of neural retina development IMP
IMP: Inferred from mutant phenotype
22323600 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
19389377 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: Inferred from mutant phenotype
15466159 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-like protein 4

  • delta-like 4

  • drosophila Delta homolog 4

Recombinant Dll4 Proteins

Cat. No. Product Name Accession Purity
HY-P75292 Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) Q9JI71 (S28-P525) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75293 Delta-like protein 4/DLL4 Protein, Mouse (HEK293, Fc) Q9JI71 (S28-P525) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P99377 Navicixizumab Inhibitor 99.83% Phase 3
HY-P991033 Tovecimig 97.39% Phase 3
HY-P99261 Demcizumab Inhibitor 99.37% Phase 2
HY-P99852 Dilpacimab 96.88% Phase 2
HY-P991423 MEDI0639 Inhibitor 98.78% Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122094 Steppogenin Inhibitor 99.49% Unkown
HY-N11709 Theasaponin E1 99.08% Unkown
HY-RS16878 Dll4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03810 DLL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23320 Dll4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99925 Enoticumab Inhibitor 99.64% Unkown
HY-P990252 Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dll4 NCBI NCBI:54567