LRRN3 - leucine rich repeat neuronal 3 Gene

Also Known as NLRR3; NLRR-3; FIGLER5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54674

About LRRN3

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:111,091,127-111,125,454 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 25 paralogues. Biased expression in adrenal (RPKM 13.7), brain (RPKM 11.9) and 12 other tissues.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRRN3 Products (3)

mRNA Protein Name
NM_001099658.2 NP_001093128.1 leucine-rich repeat neuronal protein 3 precursor
NM_001099660.2 NP_001093130.1 leucine-rich repeat neuronal protein 3 precursor
NM_018334.5 NP_060804.3 leucine-rich repeat neuronal protein 3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRN3 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (28 - 68)

LRR_8

LRR_8: Leucine rich repeat (116 - 176)

LRR_8

LRR_8: Leucine rich repeat (213 - 272)

LRR_8

LRR_8: Leucine rich repeat (310 - 370)

I-set

I-set: Immunoglobulin I-set domain (428 - 513)

fn3

fn3: Fibronectin type III domain (526 - 593)

  • 0
  • 200
  • 400
  • 600
  • 708 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat neuronal protein 3

  • fibronectin type III, immunoglobulin and leucine rich repeat domains 5

LRRN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRN3 Q9H3W5 CALML5 Homo sapiens Q9NZT1
Anti Tag CoIP
28514442
Intra
LRRN3 Q9H3W5 CALML5 Homo sapiens Q9NZT1
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRRN3 Proteins

Cat. No. Product Name Accession Purity
HY-P77067 LRRN3/NLRR-3 Protein, Human (sf9, His) Q9H3W5 (M1-T628) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Vascular Skin Disease

  • Skin Diseases, Vascular

  • Skin Vascular Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07838 LRRN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20984 Lrrn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27501 Lrrn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRRN3 MGD MGI:106036
Rattus norvegicus LRRN3 RGD RGD:71066
Felis catus LRRN3 VGNC VGNC:63312
Macaca mulatta LRRN3 VGNC VGNC:81716
Canis familiaris LRRN3 VGNC VGNC:42826
Bos taurus LRRN3 VGNC VGNC:31040
Others LRRN3 NCBI