PPID - peptidylprolyl isomerase D Gene

Also Known as CYPD; CYP-40

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5481

About PPID

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,709,127-158,723,396 (from NCBI)

This gene has 3 transcripts (splice variants), 243 orthologues and 22 paralogues. Ubiquitous expression in testis (RPKM 15.6), duodenum (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to Other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]

PPID Products (1)

mRNA	Protein	Name
NM_005038.3	NP_005029.1	peptidyl-prolyl cis-trans isomerase D

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	12145316	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables peptidyl-prolyl cis-trans isomerase activity	IDA IDA: Inferred from direct assay	11350175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9659917	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	9659917	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to UV-A	IMP IMP: Inferred from mutant phenotype	23220213	GOA
involved in chaperone-mediated protein folding	IDA IDA: Inferred from direct assay	11350175	GOA
involved in lipid droplet organization	IMP IMP: Inferred from mutant phenotype	21711559	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18708059	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23220213	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	21711559	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19932913	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	18708059	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11525244	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	11525244	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPID Protein Structure

Pro_isomerase

TPR_7

TPR_11

0
100
200
300
370 a.a.

Protein Preferred Names	Protein Names
peptidyl-prolyl cis-trans isomerase D	40 kDa peptidyl-prolyl cis-trans isomerase D

PPID Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPID	Q08752	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	Anti Bait CoIP	18806802
Intra	PPID	Q08752	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	SPR	18806802
Intra	PPID	Q08752	UROD	Homo sapiens	P06132	Anti Tag CoIP	28514442
Intra	PPID	Q08752	UROD	Homo sapiens	P06132	Anti Tag CoIP	33961781
Intra	PPID	Q08752	RACK1	Homo sapiens	P63244	Anti Tag CoIP	21146485
Intra	PPID	Q08752	RACK1	Homo sapiens	P63244	TAP	21146485
Intra	PPID	Q08752	RPS3	Homo sapiens	P23396	TAP	21146485
Intra	PPID	Q08752	RPS3	Homo sapiens	P23396	Anti Tag CoIP	21146485
Intra	PPID	Q08752	XRCC6	Homo sapiens	P12956	TAP	21146485
Intra	PPID	Q08752	XRCC6	Homo sapiens	P12956	Anti Tag CoIP	21146485
Intra	PPID	Q08752	ILF2	Homo sapiens	Q12905	TAP	21146485
Intra	PPID	Q08752	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	EM	18806802
Intra	PPID	Q08752	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	Confocal	18806802
Intra	PPID	Q08752	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR	18806802
Intra	PPID	Q08752	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	Anti Bait CoIP	18806802
Cross	PPID	Q08752	MYB	Gallus gallus	P01103	Pull Down	9659917

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PPID Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71224	PPID Protein, Human (His, solution)	Q08752 (M1-A370)	≥ 90%, as determined by reducing SDS-PAGE.

PPID Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82354	Cyclophilin 40 Antibody (YA2099)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P84513	Cyclophilin 40 Antibody (YA4210)	IHC-P, FC, ELISA	Human
HY-P84513A	Cyclophilin 40 Antibody (YA4210)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10949	PPID Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181062	VWK147		/	Unkown
HY-RS19372	Ppid Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25864	Ppid Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPID	RGD	RGD:1303174
Bos taurus	PPID	VGNC	VGNC:33197
Canis familiaris	PPID	VGNC	VGNC:44851
Felis catus	PPID	VGNC	VGNC:79975
Mus musculus	PPID	MGD	MGI:1914988
Others	PPID	NCBI