ATG2B - autophagy related 2B Gene

Also Known as BLTP4B; C14orf103

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55102

About ATG2B

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,279,195-96,363,341 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.1), skin (RPKM 7.0) and 25 other tissues.

Summary

This gene encodes a protein required for Autophagy. The encoded protein is involved in autophagosome formation. A germline duplication of a region that includes this gene is associated with predisposition to myeloid malignancies. [provided by RefSeq, Jul 2016]

ATG2B Products (1)

mRNA Protein Name
NM_018036.7 NP_060506.6 autophagy-related protein 2 homolog B

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables lipid transfer activity IDA
IDA: Inferred from direct assay
31721365 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG2B Protein Structure

Chorein_N

Chorein_N: N-terminal region of Chorein or VPS13 (16 - 110)

ATG2_CAD

ATG2_CAD: Autophagy-related protein 2 CAD motif (1295 - 1361)

ATG_C

ATG_C: Autophagy-related protein C terminal domain (1980 - 2074)

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  • 1600
  • 2000
  • 2078 a.a.
Protein Preferred Names Protein Names

autophagy-related protein 2 homolog B

  • ATG2 autophagy related 2 homolog B

ATG2B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATG2B Q96BY7 WDR45 Homo sapiens Q9Y484
Anti Tag CoIP
35271311
Intra
ATG2B Q96BY7 WDR45 Homo sapiens Q9Y484
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01146 ATG2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20862 Atg2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27377 Atg2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG2B VGNC VGNC:26255
Mus musculus ATG2B MGD MGI:1923809
Canis familiaris ATG2B VGNC VGNC:38222
Macaca mulatta ATG2B VGNC VGNC:84310
Rattus norvegicus ATG2B RGD RGD:1304878
Felis catus ATG2B VGNC VGNC:60001
Others ATG2B NCBI