WSB2 - WD repeat and SOCS box containing 2 Gene

Also Known as SBA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55884

About WSB2

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 65.4), thyroid (RPKM 28.5) and 25 other tissues.

Summary

This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

WSB2 Products (3)

mRNA Protein Name
NM_001278557.1 NP_001265486.1 WD repeat and SOCS box-containing protein 2 isoform 1
NM_001278558.2 NP_001265487.1 WD repeat and SOCS box-containing protein 2 isoform 3
NM_018639.5 NP_061109.1 WD repeat and SOCS box-containing protein 2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WSB2 Protein Structure

WD40

WD40: WD domain, G-beta repeat (93 - 139)

WD40

WD40: WD domain, G-beta repeat (146 - 182)

WD40

WD40: WD domain, G-beta repeat (187 - 225)

WD40

WD40: WD domain, G-beta repeat (231 - 267)

WD40

WD40: WD domain, G-beta repeat (292 - 320)

WD40

WD40: WD domain, G-beta repeat (338 - 360)

SOCS_box

SOCS_box: SOCS box (367 - 402)

  • 0
  • 100
  • 200
  • 300
  • 404 a.a.
Protein Preferred Names Protein Names

WD repeat and SOCS box-containing protein 2

  • CS box-containing WD protein

WSB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WSB2 Q9NYS7 PFDN2 Homo sapiens Q9UHV9
Lumier
25036637
Intra
WSB2 Q9NYS7 PFDN2 Homo sapiens Q9UHV9
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15850 WSB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WSB2 VGNC VGNC:36972
Canis familiaris WSB2 VGNC VGNC:48436
Mus musculus WSB2 MGD MGI:2144041
Rattus norvegicus WSB2 RGD RGD:1359599
Felis catus WSB2 VGNC VGNC:67092
Others WSB2 NCBI