IRGC - immunity related GTPase cinema Gene

Also Known as IFGGE; IRGC1; Iigp5; CINEMA; R30953_1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56269

About IRGC

This gene has 2 transcripts (splice variants), 395 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 28.8).

Summary

Predicted to enable GTPase activity. Predicted to be involved in cellular response to interferon-beta and defense response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

IRGC Products (1)

mRNA Protein Name
NM_019612.4 NP_062558.1 interferon-inducible GTPase 5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in lipid droplet IDA
IDA: Inferred from direct assay
37195149 GOA
located in sperm flagellum IDA
IDA: Inferred from direct assay
37195149 GOA
located in sperm mitochondrial sheath IDA
IDA: Inferred from direct assay
37195149 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IRGC Protein Structure

IIGP

IIGP: Interferon-inducible GTPase (IIGP) (22 - 345)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 463 a.a.
Protein Preferred Names Protein Names

interferon-inducible GTPase 5

  • immunity-related GTPase cinema 1

IRGC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IRGC Q6NXR0 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra
IRGC Q6NXR0 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra
IRGC Q6NXR0 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
Intra
IRGC Q6NXR0 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chronic Inflammatory Demyelinating Polyneuritis

  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Japanese Spotted Fever

  • Oriental Spotted Fever

  • Rickettsia Japonica Spotted Fever
Ureterolithiasis

  • Calculus Of Ureter

  • Ureteric Stone

  • Ureteral Calculi

  • Ureteric Calculus

  • Stone In The Ureter

  • Ureter Calculi

  • Ureteral Calculus Or Stone

  • Ureterolith

  • Ureterolithiasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06914 IRGC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IRGC RGD RGD:1311107
Bos taurus IRGC VGNC VGNC:30281
Mus musculus IRGC MGD MGI:2685948
Others IRGC NCBI