Gps2 - G protein pathway suppressor 2 Gene

Also Known as GPS-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56310

Summary

Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Part of transcription repressor complex. Orthologous to human GPS2 (G protein pathway suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Gps2 Products (2)

mRNA Protein Name
NM_001357906.2 NP_001344835.1 G protein pathway suppressor 2
NM_019726.5 NP_062700.2 G protein pathway suppressor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18218630 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
24953653 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
25519902 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
28039360 MGI
involved in negative regulation of B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28039360 MGI
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
22424771 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22666460 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
22424771 MGI
involved in negative regulation of protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
22424771 MGI
involved in negative regulation of protein K63-linked ubiquitination IMP
IMP: Inferred from mutant phenotype
28039360 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28039360 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25519902 MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
22424771 MGI
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: Inferred from direct assay
24953653 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24953653 MGI
involved in regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
24953653 MGI
involved in regulation of lipid metabolic process IDA
IDA: Inferred from direct assay
24953653 MGI
involved in response to mitochondrial depolarisation IDA
IDA: Inferred from direct assay
29499132 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22424771 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
29499132 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18218630 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
25519902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein pathway suppressor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05758 GPS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20280 Gps2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26788 Gps2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gps2 NCBI NCBI:2874