PPAN - peter pan homolog Gene

Also Known as SSF; SSF1; SSF2; BXDC3; SSF-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56342

About PPAN

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,106,223-10,112,012 (from NCBI)

This gene has 8 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in appendix (RPKM 9.7), spleen (RPKM 9.5) and 25 other tissues.

Summary

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

PPAN Products (3)

mRNA Protein Name
NM_001346139.1 NP_001333068.1 suppressor of SWI4 1 homolog isoform 2
NM_001346141.1 NP_001333070.1 suppressor of SWI4 1 homolog isoform 4
NM_020230.7 NP_064615.3 suppressor of SWI4 1 homolog isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15302935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPAN Protein Structure

Brix

Brix: Brix domain (33 - 286)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

suppressor of SWI4 1 homolog

  • brix domain-containing protein 3

Related Diseases

Diseases Alias
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Neurodegeneration With Brain Iron Accumulation 4

  • NBIA4

  • Mpan

  • Mitochondrial Protein-Associated Neurodegeneration

  • Nbia Due To C19orf12 Mutation

  • Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation

  • Neurodegeneration With Brain Iron Accumulation Type 4

  • Mitochondrial Membrane Protein Associated Neurodegeneration

  • Neurodegeneration, With Brain Iron Accumulation, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10916 PPAN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10917 Ppan Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10918 Ppan Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPAN MGD MGI:2178445
Rattus norvegicus PPAN RGD RGD:1306325