PRSS1 - serine protease 1 Gene

Homo sapiens

Also known as TRP1; TRY1; TRY4; TRYP1

Gene ID: 5644 | Gene type: protein coding

About PRSS1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:142,749,472-142,753,072 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 492 orthologues, 3 paralogues and is associated with 3 phenotypes. Restricted expression toward pancreas (RPKM 45120.4).

Summary

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This Enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

PRSS1 Products(1)

mRNA	Protein	Name
NM_002769.5	NP_002760.1	serine protease 1 preproprotein

PRSS1 Protein Structure

Trypsin

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

serine protease 1

TCR V beta 4.1

Related Diseases

Diseases

Alias

Pancreatitis, Hereditary

Hereditary Pancreatitis	Chronic Pancreatitis
Hereditary Chronic Pancreatitis	Hp
Pancreatitis, Chronic, Susceptibility To	PCTT
Hpc	Pancreatitis, Chronic
Pancreatitis, Chronic, Protection Against	Autosomal Dominant Hereditary Pancreatitis
Familial Pancreatitis	Cp
Pancreatitis Hereditary

Trypsinogen Deficiency

Pancreatic Trypsinogen Deficiency

Vitamin D-Dependent Rickets, Type 2a

Hvdrr	Generalized Resistance To 1,25-Dihydroxyvitamin D
Hypocalcemic Vitamin D-Resistant Rickets	VDDR2A
Rickets, Hereditary Vitamin D-Resistant	Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol
Pddr Iia	Rickets-Alopecia Syndrome
Rickets, Vitamin D-Resistant, Type Iia	Vitamin D-Dependent Rickets Type 2a
Vitamin D-Dependent Rickets, Type 2	Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia
Generalized 1,25-Dihydroxyvitamin D	Pseudovitamin D-Deficiency, Type Iia
Hereditary Vitamin D-Resistant Rickets	Vddr Ii
Vdrr Ii	Vitamin D-Dependent Rickets Type Ii
Vitamin D-Resistant Rickets Type Ii	Rickets Vitamin D-Dependent 2a
Pseudovitamin D-Deficiency Type Iia	Rickets Hereditary Vitamin D-Resistant
Type Iia Rickets	Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia
Vitamin D-Dependent Rickets, Type Ii	Familial Hypophosphatemic Rickets
Hypophosphatemic Rickets, X-Linked Dominant

Prss1-Related Hereditary Pancreatitis

Pancreatitis

Mumps Pancreatitis

Linitis Plastica

Leather-Bottle Stomach

Alcoholic Pancreatitis

Pancreatitis, Alcoholic

Pancreatitis Alcoholic

Dysplastic Nevus Syndrome

Familial Atypical Multiple Mole-Melanoma	Familial Atypical Multiple Mole Melanoma Syndrome
Melanoma-Pancreatic Cancer Syndrome	Famm Syndrome
B-K Mole Syndrome	Famm-Pc Syndrome
Fammm Syndrome	Familial Atypical Mole Syndrome
Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome	Familial Dysplastic Nevus Syndrome
Familial Atypical Multiple Mole Melanoma	Dysplastic Nevus
Familial Atypical Mole Melanoma Syndrome

Tropical Calcific Pancreatitis

Tropical Pancreatitis	TCP
Fibrocalculous Pancreatic Diabetes	Tropical Calcific Chronic Pancreatitis
Fibrocalculous Pancreatic Diabetes, Susceptibility To	Tcp - [Tropical Chronic Pancreatitis]

Biliary Dyskinesia

Sphincter Of Oddi Dysfunction

Pancreatic Steatorrhea

Pancreatic Steatorrhoea	Decreased Tolerance Of Pancreas
Pancreatic Disturbance Of Fat Absorption

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Van Maldergem Syndrome 1

Cerebrofacioarticular Syndrome	VMLDS1
Van Maldergem Syndrome	Cerebro-Facio-Articular Syndrome
Van Maldergem Wetzburger Verloes Syndrome

Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Pancreas, Annular

Annular Pancreas	Pancreas Annulare
Congenital Annular Pancreas

Duodenal Obstruction

Bile Duct Cysts

Choledochal Cyst	Choledochal Cysts
Choledochocele	Biliary Cyst
Congenital Choledochal Cyst	Bile Duct Cyst
Congenital Cystic Dilatation Of The Biliary Tract	Congenital Bile Duct Dilatation

Exocrine Pancreatic Insufficiency

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction	Chronic Intestinal Pseudo-Obstruction
Cipo	Neuronal Intestinal Dysplasia
Hollow Visceral Myopathy	Familial Visceral Neuropathy
Paralytic Ileus	Intestinal Pseudoobstruction
Chronic Idiopathic Intestinal Pseudo-Obstruction	Ciip
Congenital Short Bowel Syndrome	Enteric Neuropathy
Familial Visceral Myopathy	Ipo
Pseudo-Obstruction Of Intestine	Pseudointestinal Obstruction Syndrome
Pseudoobstructive Syndrome	Congenital Idiopathic Intestinal Pseudoobstruction
Visceral Myopathy, Familial

Trichothiodystrophy 7, Nonphotosensitive

TTD7	Nonphotosensitive Trichothiodystrophy 7
Trichothiodystrophy 7, Non-Photosensitive

Common Bile Duct Disease

Common Bile Duct Diseases

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer	HDGC
LBC	Familial Diffuse Gastric Cancer
Fdgc	Hereditary Diffuse Gastric Adenocarcinoma
Breast Cancer, Lobular	Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate
DGLBC	Gastric Cancer, Hereditary Diffuse
Gastric Cancer, Familial Diffuse Breast Cancer, Lobular	Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate
E-Cadherin-Associated Hereditary Gastric Cancer	Familial Diffuse Cancer Of Stomach
Hereditary Diffuse Cancer Of Stomach	Gastric Cancer Familial Diffuse
Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate	Cancer, Gastric, Hereditary Diffuse

3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome	Malpuech Facial Clefting Syndrome
Oculopalatoskeletal Syndrome	Carnevale Syndrome
Michels Syndrome	Malpuech-Michels-Mingarelli-Carnevale Syndrome
Carnevale-Krajewska-Fischetto Syndrome	Craniosynostosis With Lid Anomalies
Malpuech Syndrome	Mingarelli Syndrome
Oculo-Skeletal-Abdominal Syndrome	Osa Syndrome
Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia	Ptosis-Strabismus-Rectus Abdominis Diastasis

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Lynch Syndrome

Hereditary Nonpolyposis Colon Cancer	Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Carcinoma	Hereditary Nonpolyposis Colorectal Neoplasms
Familial Nonpolyposis Colon Cancer	Hnpcc
Coca 1	Hereditary Defective Mismatch Repair Syndrome
Hereditary Non-Polyposis Colon Cancer	Hereditary Non-Polyposis Colon Cancer Syndrome
Hereditary Non-Polyposis Colorectal Cancer	Hereditary Non-Polyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colon Cancer Syndrome	Hereditary Nonpolyposis Colorectal Cancer Syndrome
Hereditary Nonpolyposis Colorectal Neoplasm	Hnpcc - Hereditary Nonpolyposis Colon Cancer
Cancer Family Syndrome	Familial Nonpolyposis Colorectal Cancer
Colon Cancer, Familial Nonpolyposis	Colorectal Neoplasms, Hereditary Nonpolyposis
Cancer, Colorectal, Nonpolyposis, Hereditary	Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

Melanoma, Cutaneous Malignant 1

Familial Melanoma	Melanoma, Cutaneous Malignant, Susceptibility To, 1
Melanoma, Malignant	CMM1
Melanoma, Cutaneous Malignant	Cmm
Familial Atypical Mole-Malignant Melanoma Syndrome	Fammm
Melanoma, Familial	Mlm
Dysplastic Nevus Syndrome, Hereditary	Dns
B-K Mole Syndrome	Melanoma, Cutaneous Malignant, 1
Malignant Melanoma, Cutaneous	Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1
Dysplastic Nevus Syndrome	Cutaneous Melanoma
Familial Atypical Mole Melanoma Syndrome	Hereditary Melanoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11245	PRSS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRSS1	RGD	RGD:3417
Mus musculus	PRSS1	NCBI
Others	PRSS1	NCBI

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