Clec4e - C-type lectin domain family 4, member e Gene

Also Known as Mincle; Clecsf9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56619

Summary

Enables glycolipid binding activity and pattern recognition receptor activity. Involved in Antifungal innate immune response and positive regulation of cytokine production. Acts upstream of or within Fc-gamma Receptor signaling pathway; T cell differentiation involved in immune response; and defense response to bacterium. Is active in phagocytic vesicle membrane and plasma membrane. Orthologous to human CLEC4E (C-type lectin domain family 4 member E). [provided by Alliance of Genome Resources, Apr 2022]

Clec4e Products (1)

mRNA Protein Name
NM_019948.2 NP_064332.1 C-type lectin domain family 4 member E

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycolipid binding IPI
IPI: Inferred from physical interaction
20008526 MGI
enables pattern recognition receptor activity IDA
IDA: Inferred from direct assay
20008526 MGI
enables pattern recognition receptor activity IMP
IMP: Inferred from mutant phenotype
18490740 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18776906 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
18776906 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Fc-gamma receptor signaling pathway IDA
IDA: Inferred from direct assay
23602766 MGI
acts upstream of or within T cell differentiation involved in immune response IMP
IMP: Inferred from mutant phenotype
23602766 MGI
involved in antifungal innate immune response IMP
IMP: Inferred from mutant phenotype
18490740 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
23602766 MGI
involved in immune response IMP
IMP: Inferred from mutant phenotype
19171887 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
20008526 MGI
acts upstream of or within innate immune response IMP
IMP: Inferred from mutant phenotype
23602766 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
18776906 MGI
Cellular Component GO Annotation Evidence References Source
is active in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
18490740 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
18490740 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-type lectin domain family 4 member E

  • C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9

  • C-type lectin, superfamily member 9

  • macrophage-inducible C-type lectin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02794 CLEC4E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17848 Clec4e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24316 Clec4e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clec4e NCBI NCBI:26253