Aldh1a3 - aldehyde dehydrogenase family 1, subfamily A3 Gene

Also Known as V1; ALDH6; RALDH3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56847

Summary

Enables NAD+ binding activity; aldehyde dehydrogenase (NAD+) activity; and thyroid hormone binding activity. Involved in Harderian gland development; embryonic camera-type eye development; and nose development. Acts upstream of or within several processes, including nucleus accumbens development; righting reflex; and sensory organ development. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a3 Products (1)

mRNA Protein Name
NM_053080.3 NP_444310.3 aldehyde dehydrogenase family 1 member A3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD+ binding IDA
IDA: Inferred from direct assay
16241904 MGI
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
11013254 MGI
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
11044606 MGI
enables thyroid hormone binding IPI
IPI: Inferred from physical interaction
16241904 MGI
Biological Process GO Annotation Evidence References Source
involved in Harderian gland development IMP
IMP: Inferred from mutant phenotype
14623956 MGI
acts upstream of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16207763 MGI
acts upstream of or within embryonic camera-type eye development IGI
IGI: Inferred from genetic interaction
17184764 MGI
involved in embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
14623956 MGI
acts upstream of or within embryonic eye morphogenesis IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within embryonic eye morphogenesis IMP
IMP: Inferred from mutant phenotype
16207763 MGI
acts upstream of or within face development IGI
IGI: Inferred from genetic interaction
17184764 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: Inferred from mutant phenotype
23536097 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
23536097 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
23536097 MGI
involved in nose development IMP
IMP: Inferred from mutant phenotype
14623956 MGI
acts upstream of or within nucleus accumbens development IMP
IMP: Inferred from mutant phenotype
17207476 MGI
acts upstream of or within olfactory pit development IMP
IMP: Inferred from mutant phenotype
17207476 MGI
acts upstream of or within optic cup morphogenesis involved in camera-type eye development IGI
IGI: Inferred from genetic interaction
16611695 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16207763 MGI
acts upstream of or within retinoic acid biosynthetic process IDA
IDA: Inferred from direct assay
11013254 MGI
involved in retinoic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
14623956 MGI
acts upstream of or within retinoic acid metabolic process IGI
IGI: Inferred from genetic interaction
16207763 MGI
acts upstream of or within retinoic acid metabolic process IMP
IMP: Inferred from mutant phenotype
16207763 MGI
acts upstream of or within righting reflex IMP
IMP: Inferred from mutant phenotype
23536097 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16615129 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldehyde dehydrogenase family 1 member A3

  • RALDH-3

  • aldehyde dehydrogenase-6

  • retinaldehyde dehydrogenase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W015273A trans-3-Indoleacrylic acid Inhibitor 99.77% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-144667 ALDH1A3-IN-1 Inhibitor 98.05% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-W017186 ALDH1A3-IN-3 Inhibitor 99.26% Unkown
HY-164781 KOTX1 Inhibitor 98.94% Unkown
HY-169884 MCI-INI-3 Inhibitor 99.23% Unkown
HY-144669 ALDH1A3-IN-2 Inhibitor 99.85% Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-RS23346 Aldh1a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-RS00564 ALDH1A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169883 PKM2-IN-7 Inhibitor / Unkown
HY-RS16904 Aldh1a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1a3 NCBI NCBI:220