Vav3 - vav 3 oncogene Gene

Also Known as Idd18.1; A530094I06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57257

Summary

Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase activity. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb segment; metanephros; and sensory organ. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Vav3 Products (3)

mRNA Protein Name
NM_001378987.1 NP_001365916.1 guanine nucleotide exchange factor VAV3 isoform 3
NM_020505.2 NP_065251.2 guanine nucleotide exchange factor VAV3 isoform 1
NM_146139.2 NP_666251.1 guanine nucleotide exchange factor VAV3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
15728722 MGI
enables guanyl-nucleotide exchange factor activity IGI
IGI: Inferred from genetic interaction
15249579 MGI
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
15728722 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16782872 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within cell projection assembly IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within integrin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
15249579 MGI
acts upstream of or within lamellipodium assembly IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within positive regulation of cell adhesion IGI
IGI: Inferred from genetic interaction
15249579 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15728722 MGI
acts upstream of or within regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
15249579 MGI
acts upstream of or within small GTPase-mediated signal transduction IMP
IMP: Inferred from mutant phenotype
15728722 MGI
acts upstream of or within vesicle fusion IGI
IGI: Inferred from genetic interaction
15249579 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15728722 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15728722 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide exchange factor VAV3

  • VAV-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15614 VAV3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20835 Vav3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27349 Vav3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vav3 NCBI NCBI:10451