TMCC3 - transmembrane and coiled-coil domain family 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57458

About TMCC3

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:94,567,122-94,650,557 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 11.8), small intestine (RPKM 10.1) and 24 other tissues.

Summary

Enables 14-3-3 protein binding activity and identical protein binding activity. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

TMCC3 Products (2)

mRNA Protein Name
NM_001301036.2 NP_001287965.1 transmembrane and coiled-coil domain protein 3 isoform 2
NM_020698.4 NP_065749.3 transmembrane and coiled-coil domain protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
27697108 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
27697108 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24454821 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
27697108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMCC3 Protein Structure

Tmemb_cc2

Tmemb_cc2: Predicted transmembrane and coiled-coil 2 protein (64 - 466)

  • 0
  • 100
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  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

transmembrane and coiled-coil domain protein 3

  • transmembrane and coiled-coil domains 3

TMCC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMCC3 Q9ULS5 TEX28 Homo sapiens O15482
Y2H Array
32296183
Intra
TMCC3 Q9ULS5 TEX28 Homo sapiens O15482
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14631 TMCC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMCC3 VGNC VGNC:66241
Rattus norvegicus TMCC3 RGD RGD:1307241
Mus musculus TMCC3 MGD MGI:2442900
Bos taurus TMCC3 VGNC VGNC:35927
Macaca mulatta TMCC3 VGNC VGNC:79787
Canis familiaris TMCC3 VGNC VGNC:47430
Others TMCC3 NCBI