LRRN1 - leucine rich repeat neuronal 1 Gene

Also Known as NLRR1; NLRR-1; FIGLER3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57633

About LRRN1

Cytogenetic location: 3p26.2 Genomic coordinates (GRCh38): 3:3,799,431-3,849,834 (from NCBI)

This gene has 3 transcripts (splice variants), 196 orthologues and 25 paralogues. Biased expression in brain (RPKM 12.5), testis (RPKM 4.5) and 8 other tissues.

Summary

Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRRN1 Products (3)

mRNA Protein Name
NM_001324188.2 NP_001311117.1 leucine-rich repeat neuronal protein 1 precursor
NM_001324189.2 NP_001311118.1 leucine-rich repeat neuronal protein 1 precursor
NM_020873.7 NP_065924.3 leucine-rich repeat neuronal protein 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRN1 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (96 - 118)

LRR_8

LRR_8: Leucine rich repeat (120 - 177)

LRR_8

LRR_8: Leucine rich repeat (216 - 275)

LRR_8

LRR_8: Leucine rich repeat (312 - 373)

I-set

I-set: Immunoglobulin I-set domain (431 - 516)

  • 0
  • 200
  • 400
  • 600
  • 716 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat neuronal protein 1

  • fibronectin type III, immunoglobulin and leucine rich repeat domains 3

LRRN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRRN1 Q6UXK5 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
LRRN1 Q6UXK5 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Brittle Cornea Syndrome 1

  • Brittle Cornea Syndrome

  • Fragilitas Oculi With Joint Hyperextensibility

  • Dysgenesis Mesodermalis Corneae Et Sclerae

  • BCS1

  • Corneal Fragility, Keratoglobus, Blue Sclerae, Joint Hyperextensibility

  • Ehlers-Danlos Syndrome, Type Vib, Formerly

  • Eds6b, Formerly

  • Type Vib Ehlers-Danlos Syndrome

  • Eds Vib

  • Ehlers-Danlos Syndrome Type 6b

  • Corneal Fragility Keratoglobus Blue Sclerae Joint Hyperextensibility

  • Eds6b Formerly

  • Ehlers-Danlos Syndrome Type Vib Formerly

  • Ehlers-Danlos Syndrome Type 6

  • Cornea, Brittle, Syndrome

  • Cornea, Brittle, Syndrome, Type 1

  • Ehlers-Danlos Syndrome 6b
Corneal Dystrophy, Posterior Polymorphous, 1

  • Posterior Polymorphous Corneal Dystrophy

  • Ppcd

  • Maumenee Corneal Dystrophy

  • Posterior Polymorphous Corneal Dystrophy 1

  • PPCD1

  • Corneal Dystrophy, Hereditary Polymorphous Posterior

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant

  • Schlichting Dystrophy

  • Ched1

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

  • Ched1, Formerly

  • Hereditary Polymorphus Posterior Corneal Dystrophy

  • Posterior Polymorphous Dystrophy

  • Hereditary Polymorphous Posterior Corneal Dystrophy

  • Dystrophy, Corneal, Posterior Polymorphous

  • Dystrophy, Corneal, Posterior Polymorphous, Type 1

  • Polymorphous Corneal Dystrophy

  • Corneal Endothelial Dystrophy 2
Malignant Inflammatory Fibrous Histiocytoma

  • Inflammatory Mfh

  • Xanthosarcoma
Differentiating Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07780 LRCH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07836 LRRN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LRRN1 VGNC VGNC:74324
Mus musculus LRRN1 MGD MGI:106038
Felis catus LRRN1 VGNC VGNC:82360
Rattus norvegicus LRRN1 RGD RGD:1564145
Canis familiaris LRRN1 VGNC VGNC:42824
Bos taurus LRRN1 VGNC VGNC:31039
Others LRRN1 NCBI