PHF12 - PHD finger protein 12 Gene

Homo sapiens

Also known as PF1

Gene ID: 57649 | Gene type: protein coding

About PHF12

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,905,250-28,951,518 (from NCBI)

This gene has 17 transcripts (splice variants), 252 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 8.9), spleen (RPKM 8.2) and 25 other tissues.

Summary

Enables phosphatidylinositol binding activity and transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of Sin3 complex and transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

PHF12 Products(3)

mRNA	Protein	Name
NM_001033561.2	NP_001028733.1	PHD finger protein 12 isoform 1
NM_001290131.2	NP_001277060.1	PHD finger protein 12 isoform 3
NM_020889.3	NP_065940.1	PHD finger protein 12 isoform 2

PHF12 Protein Structure

PHD

0
200
400
600
800
1004 a.a.

Protein Preferred Names

Protein Names

PHD finger protein 12

PHD factor 1

Related Diseases

Diseases

Alias

Peroneal Nerve Paralysis

Peroneal Nerve Palsy

Heel Spur

Calcaneal Spur

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10416	PHF12 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHF12	VGNC	VGNC:44482
Macaca mulatta	PHF12	VGNC	VGNC:75838
Felis catus	PHF12	VGNC	VGNC:64138
Rattus norvegicus	PHF12	RGD	RGD:1305731
Mus musculus	PHF12	MGD	MGI:1924057
Bos taurus	PHF12	VGNC	VGNC:32814

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