Zbp1 - Z-DNA binding protein 1 Gene

Also Known as Dai; Dlm1; mZaDLM; 2010010H03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58203

Summary

Enables double-stranded RNA binding activity and left-handed Z-DNA binding activity. Involved in several processes, including positive regulation of defense response; positive regulation of programmed cell death; and regulation of interleukin-1-mediated signaling pathway. Acts upstream of or within positive regulation of type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in eye and heart. Orthologous to human ZBP1 (Z-DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Zbp1 Products (2)

mRNA Protein Name
NM_001139519.1 NP_001132991.1 Z-DNA-binding protein 1 isoform 2
NM_021394.2 NP_067369.2 Z-DNA-binding protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
17618271 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
32200799 MGI
enables left-handed Z-DNA binding IDA
IDA: Inferred from direct assay
11524677 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22423968 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
32200799 MGI
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
32350114 MGI
involved in defense response to fungus IMP
IMP: Inferred from mutant phenotype
33109609 MGI
involved in defense response to virus IDA
IDA: Inferred from direct assay
22423968 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
27917412 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
27746097 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
27917412 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
27819681 MGI
involved in positive regulation of necroptotic process IDA
IDA: Inferred from direct assay
22423968 MGI
involved in positive regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
27819681 MGI
acts upstream of or within positive regulation of type I interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17618271 MGI
involved in pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
27917412 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
31630209 MGI
involved in regulation of interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
31630209 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28607035 MGI
located in nucleus IDA
IDA: Inferred from direct assay
28607035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Z-DNA-binding protein 1

  • DNA-dependent activator of IFN-regulatory factors

  • tumor stroma and activated macrophage protein DLM-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2397 9''-Methyl salvianolate B 99.54% Unkown
HY-144873 AVJ16 Inducer 99.60% Unkown
HY-181129 ADAR1i-124 98.71% Unkown
HY-N0417 Cucurbitacin E 99.92% Unkown
HY-162424 ZBP1/RIP3/MLKL activator 1 Activator 99.73% Unkown
HY-RS15958 ZBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16687 Zbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177119 ZBP1 Covalent PROTAC-1 Inhibitor 96.87% Unkown
HY-181850 Telomeric G4s ligand 2 / Unkown
HY-185102 ZBP1 PROTAC-1 / Unkown
HY-RS16849 Igf2bp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23122 Zbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23290 Igf2bp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zbp1 NCBI NCBI:81030