ZBP1 - Z-DNA binding protein 1 Gene

Also Known as DAI; DLM1; DLM-1; C20orf183

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81030

About ZBP1

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,603,852-57,620,426 (from NCBI)

This gene has 9 transcripts (splice variants) and 83 orthologues. Biased expression in spleen (RPKM 3.6), appendix (RPKM 3.2) and 13 other tissues.

Summary

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

ZBP1 Products (5)

mRNA	Protein	Name
NM_001160417.2	NP_001153889.1	Z-DNA-binding protein 1 isoform b
NM_001160418.2	NP_001153890.1	Z-DNA-binding protein 1 isoform c
NM_001160419.3	NP_001153891.1	Z-DNA-binding protein 1 isoform d
NM_001323966.2	NP_001310895.1	Z-DNA-binding protein 1 isoform e
NM_030776.3	NP_110403.2	Z-DNA-binding protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	17618271	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	34192517	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19095800	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19590578	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	34192517	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	32200799	GOA
involved in positive regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	32200799	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16876127	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17618271	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16876127	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBP1 Protein Structure

z-alpha

RHIM

0
100
200
300
400
429 a.a.

Protein Preferred Names	Protein Names
Z-DNA-binding protein 1	DNA-dependent activator of IRFs

ZBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZBP1	Q9H171	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	19590578
Intra	ZBP1	Q9H171	KRR1	Homo sapiens	Q13601	Anti Tag CoIP	19590578

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71436	ZBP1 Protein, Human (His)	Q9H171-1 (M1-S149)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Zika Virus Congenital Syndrome	Zikv Congenital Infection
Variola Minor	Alastrim Cottonpox Milkpox Whitepox
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2397	9''-Methyl salvianolate B		99.54%	Unkown
HY-144873	AVJ16	Inducer	99.60%	Unkown
HY-181129	ADAR1i-124		98.71%	Unkown
HY-N0417	Cucurbitacin E		99.92%	Unkown
HY-162424	ZBP1/RIP3/MLKL activator 1	Activator	99.73%	Unkown
HY-RS15958	ZBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06619	IGF2BP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16687	Zbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177119	ZBP1 Covalent PROTAC-1	Inhibitor	96.87%	Unkown
HY-181850	Telomeric G4s ligand 2		/	Unkown
HY-185102	ZBP1 PROTAC-1		/	Unkown
HY-RS16849	Igf2bp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23122	Zbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23290	Igf2bp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZBP1	RGD	RGD:619956
Macaca mulatta	ZBP1	VGNC	VGNC:79013
Mus musculus	ZBP1	MGD	MGI:1927449
Canis familiaris	ZBP1	VGNC	VGNC:54745
Felis catus	ZBP1	VGNC	VGNC:81262
Bos taurus	ZBP1	VGNC	VGNC:37056
Others	ZBP1	NCBI