SRPRB - SRP receptor subunit beta Gene

Also Known as APMCF1; SR-beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58477

About SRPRB

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,784,023-133,828,574 (from NCBI)

This gene has 6 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues.

Summary

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

SRPRB Products (2)

mRNA Protein Name
NM_001379313.1 NP_001366242.1 signal recognition particle receptor subunit beta
NM_021203.4 NP_067026.3 signal recognition particle receptor subunit beta

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19664239 GOA
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
23264731 GOA
located in membrane IDA
IDA: Inferred from direct assay
22375059 GOA
part of signal recognition particle receptor complex EXP
EXP: Inferred from Experiment
16439358 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPRB Protein Structure

SRPRB

SRPRB: Signal recognition particle receptor beta subunit (62 - 241)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

signal recognition particle receptor subunit beta

  • SRP receptor beta subunit

Related Diseases

Diseases Alias
Testis Seminoma

  • Seminoma Of Testis

  • Seminoma Testis

  • Testicular Seminoma Pure

  • Seminoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13781 SRPRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22830 Srprb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29345 Srprb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SRPRB VGNC VGNC:102849
Mus musculus SRPRB MGD MGI:102964
Rattus norvegicus SRPRB RGD RGD:1304698
Macaca mulatta SRPRB VGNC VGNC:77980
Bos taurus SRPRB VGNC VGNC:35291
Others SRPRB NCBI