SRPRB - SRP receptor subunit beta Gene

Homo sapiens

Also known as APMCF1; SR-beta

Gene ID: 58477 | Gene type: protein coding

About SRPRB

Cytogenetic location: 3q22.1 Genomic coordinates (GRCh38): 3:133,784,023-133,828,574 (from NCBI)

This gene has 6 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues.

Summary

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

SRPRB Products(2)

mRNA	Protein	Name
NM_001379313.1	NP_001366242.1	signal recognition particle receptor subunit beta
NM_021203.4	NP_067026.3	signal recognition particle receptor subunit beta

SRPRB Protein Structure

SRPRB

0
100
200
271 a.a.

Protein Preferred Names

Protein Names

signal recognition particle receptor subunit beta

SRP receptor beta subunit

Related Diseases

Diseases

Alias

Testis Seminoma

Seminoma Of Testis	Seminoma Testis
Testicular Seminoma Pure	Seminoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13781	SRPRB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SRPRB	VGNC	VGNC:102849
Mus musculus	SRPRB	MGD	MGI:102964
Rattus norvegicus	SRPRB	RGD	RGD:1304698
Macaca mulatta	SRPRB	VGNC	VGNC:77980
Bos taurus	SRPRB	VGNC	VGNC:35291

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