JAM2 - junctional adhesion molecule 2 Gene

Homo sapiens

Also known as JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

Gene ID: 58494 | Gene type: protein coding

About JAM2

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,639,258-25,717,562 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 14 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 25.9), brain (RPKM 13.2) and 20 other tissues.

Summary

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

JAM2 Products(3)

mRNA	Protein	Name
NM_001270407.2	NP_001257336.1	junctional adhesion molecule B isoform 2 precursor
NM_001270408.2	NP_001257337.1	junctional adhesion molecule B isoform 3 precursor
NM_021219.4	NP_067042.1	junctional adhesion molecule B isoform 1 precursor

JAM2 Protein Structure

V-set

I-set

0
100
200
298 a.a.

Protein Preferred Names

Protein Names

junctional adhesion molecule B

JAM-2

Recombinant JAM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70385	JAM-B/CD322 Protein, Human (HEK293, His)	P57087 (F29-N236)	≥95%

Related Diseases

Diseases

Alias

Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive

IBGC8

Basal Ganglia Calcification, Idiopathic, 1

Primary Familial Brain Calcification	Pfbc
Bspdc	Bilateral Striopallidodentate Calcinosis
Cerebrovascular Ferrocalcinosis	IBGC1
Familial Idiopathic Basal Ganglia Calcification	Idiopathic Basal Ganglia Calcification 1
Striopallidodentate Calcinosis, Bilateral	Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset
Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset	Ferrocalcinosis, Cerebrovascular
Fahr Disease, Familial, Formerly	Basal Ganglia Calcification, Idiopathic, 3, Formerly
Ibgc3, Formerly	Basal Ganglia Calcification, Idiopathic, 2, Formerly
Ibgc2, Formerly	Fibgc
Striopallidodentate Calcinosis	Idiopathic Basal Ganglia Calcification
Ferrocalcinosis Cerebro Vascular	Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis
Familial Fahr Disease	Ibgc2
Ibgc3	Idiopathic Basal Ganglia Calcification 2
Idiopathic Basal Ganglia Calcification 3	Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification
Basal Ganglia Calcification, Idiopathic	Calcification, Basal Ganglia, Idiopathic
Calcification, Basal Ganglia, Idiopathic, Type 1	Fahr'S Syndrome

Basal Ganglia Calcification

Fahr'S Syndrome	Fahr'S Disease
Fahr Disease

Neurogenic Bowel

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07027	JAM2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	JAM2	MGD	MGI:1933820
Rattus norvegicus	JAM2	RGD	RGD:1561692
Felis catus	JAM2	VGNC	VGNC:63001
Bos taurus	JAM2	VGNC	VGNC:50011
Canis familiaris	JAM2	VGNC	VGNC:53029
Macaca mulatta	JAM2	VGNC	VGNC:73831
Others	JAM2	NCBI