JAM2 - junctional adhesion molecule 2 Gene

Also Known as JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58494

About JAM2

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,639,258-25,717,562 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 14 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 25.9), brain (RPKM 13.2) and 20 other tissues.

Summary

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

JAM2 Products (3)

mRNA Protein Name
NM_001270407.2 NP_001257336.1 junctional adhesion molecule B isoform 2 precursor
NM_001270408.2 NP_001257337.1 junctional adhesion molecule B isoform 3 precursor
NM_021219.4 NP_067042.1 junctional adhesion molecule B isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
12070135 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11590146 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
24357068 GOA
involved in cellular extravasation IDA
IDA: Inferred from direct assay
12239159 GOA
involved in hematopoietic stem cell migration to bone marrow IMP
IMP: Inferred from mutant phenotype
24357068 GOA
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
19740376 GOA
involved in lymphocyte aggregation IDA
IDA: Inferred from direct assay
11823489 GOA
involved in positive regulation of lymphocyte migration IDA
IDA: Inferred from direct assay
12239159 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19740376 GOA
located in cell-cell contact zone IDA
IDA: Inferred from direct assay
12239159 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11590146 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
31851307 GOA
part of protein complex involved in cell adhesion IDA
IDA: Inferred from direct assay
11590146 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAM2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (35 - 118)

I-set

I-set: Immunoglobulin I-set domain (145 - 223)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

junctional adhesion molecule B

  • JAM-2

JAM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
JAM2 P57087 JAM3 Homo sapiens Q9BX67
Protein Array
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant JAM2 Proteins

Cat. No. Product Name Accession Purity
HY-P70385 JAM-B/CD322 Protein, Human (HEK293, His) P57087-1 (F29-N236) ≥ 95%, as determined by reducing SDS-PAGE.

JAM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84414 CD322 Antibody (YA4111) WB, ICC/IF, FC, ELISA Human
HY-P84414A CD322 Antibody (YA4111)(PBS only) WB, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive

  • IBGC8
Basal Ganglia Calcification, Idiopathic, 1

  • Primary Familial Brain Calcification

  • Pfbc

  • Bspdc

  • Bilateral Striopallidodentate Calcinosis

  • Cerebrovascular Ferrocalcinosis

  • IBGC1

  • Familial Idiopathic Basal Ganglia Calcification

  • Idiopathic Basal Ganglia Calcification 1

  • Striopallidodentate Calcinosis, Bilateral

  • Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset

  • Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset

  • Ferrocalcinosis, Cerebrovascular

  • Fahr Disease, Familial, Formerly

  • Basal Ganglia Calcification, Idiopathic, 3, Formerly

  • Ibgc3, Formerly

  • Basal Ganglia Calcification, Idiopathic, 2, Formerly

  • Ibgc2, Formerly

  • Fibgc

  • Striopallidodentate Calcinosis

  • Idiopathic Basal Ganglia Calcification

  • Ferrocalcinosis Cerebro Vascular

  • Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis

  • Familial Fahr Disease

  • Ibgc2

  • Ibgc3

  • Idiopathic Basal Ganglia Calcification 2

  • Idiopathic Basal Ganglia Calcification 3

  • Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification

  • Basal Ganglia Calcification, Idiopathic

  • Calcification, Basal Ganglia, Idiopathic

  • Calcification, Basal Ganglia, Idiopathic, Type 1

  • Fahr'S Syndrome
Basal Ganglia Calcification

  • Fahr'S Syndrome

  • Fahr'S Disease

  • Fahr Disease
Neurogenic Bowel
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07027 JAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07028 JAM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18768 Jam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25256 Jam2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus JAM2 MGD MGI:1933820
Rattus norvegicus JAM2 RGD RGD:1561692
Felis catus JAM2 VGNC VGNC:63001
Bos taurus JAM2 VGNC VGNC:50011
Canis familiaris JAM2 VGNC VGNC:53029
Macaca mulatta JAM2 VGNC VGNC:73831
Others JAM2 NCBI