OSTC - oligosaccharyltransferase complex non-catalytic subunit Gene

Also Known as DC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 58505

About OSTC

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:108,650,599-108,667,820 (from NCBI)

This gene has 5 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 57.1), endometrium (RPKM 49.2) and 25 other tissues.

Summary

Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

OSTC Products (3)

mRNA Protein Name
NM_001267817.2 NP_001254746.1 oligosaccharyltransferase complex subunit OSTC isoform 2
NM_001267818.2 NP_001254747.1 oligosaccharyltransferase complex subunit OSTC isoform 3
NM_021227.4 NP_067050.1 oligosaccharyltransferase complex subunit OSTC isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
15835887 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSTC Protein Structure

OST3_OST6

OST3_OST6: OST3 / OST6 family, transporter family (7 - 138)

  • 0
  • 100
  • 149 a.a.
Protein Preferred Names Protein Names

oligosaccharyltransferase complex subunit OSTC

  • hydrophobic protein HSF-28

OSTC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OSTC Q9NRP0 EDA Homo sapiens Q92838
Validated Y2H
25416956
Intra
OSTC Q9NRP0 EDA Homo sapiens Q92838
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Corticosteroid Allergy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09855 OSTC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19626 Ostn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OSTC MGD MGI:1913607
Canis familiaris OSTC VGNC VGNC:44170
Felis catus OSTC VGNC VGNC:107382
Macaca mulatta OSTC VGNC VGNC:107187
Bos taurus OSTC VGNC VGNC:32478
Rattus norvegicus OSTC RGD RGD:1560708
Others OSTC NCBI