RAB13 - RAB13, member RAS oncogene family Gene

Also Known as GIG4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5872

About RAB13

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,981,650-153,990,708 (from NCBI)

This gene has 5 transcripts (splice variants), 169 orthologues and 68 paralogues. Ubiquitous expression in urinary bladder (RPKM 34.2), prostate (RPKM 33.4) and 25 other tissues.

Summary

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

RAB13 Products (2)

mRNA Protein Name
NM_001272038.2 NP_001258967.1 ras-related protein Rab-13 isoform 2
NM_002870.5 NP_002861.1 ras-related protein Rab-13 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
20937701 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
8294494 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9712853 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi to plasma membrane transport IDA
IDA: Inferred from direct assay
35343654 GOA
involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
15096524 GOA
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
15528189 GOA
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
18779367 GOA
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
20008558 GOA
involved in protein kinase A signaling IMP
IMP: Inferred from mutant phenotype
15096524 GOA
involved in protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
15096524 GOA
Cellular Component GO Annotation Evidence References Source
NOT located in Golgi apparatus IDA
IDA: Inferred from direct assay
18779367 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
8294494 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
8294494 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15528189 GOA
located in neuron projection IDA
IDA: Inferred from direct assay
20008558 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15528189 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
18779367 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
18779367 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB13 Protein Structure

Ras

Ras: Ras family (10 - 170)

  • 0
  • 100
  • 203 a.a.
Protein Preferred Names Protein Names

ras-related protein Rab-13

  • RAS-associated protein RAB13

RAB13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
RAB13 P51153 Micall2 Mus musculus Q3TN34
Y2H
16525024
Cross
RAB13 P51153 Micall2 Mus musculus Q3TN34
Anti Tag CoIP
18332111
Cross
RAB13 P51153 Micall2 Mus musculus Q3TN34
Confocal
16525024
Intra
RAB13 P51153 PDE6D Homo sapiens O43924
Pull Down
9712853
Cross
RAB13 P51153 Leprotl1 Rattus norvegicus Q6PDU4
Pull Down
23772379
Cross
RAB13 P51153 Leprotl1 Rattus norvegicus Q6PDU4
Anti Tag CoIP
23772379
Cross: Cross-species interaction Intra: Intraspecies interaction

RAB13 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84369 RAB13 Antibody (YA4066) IHC-P, ICC/IF, FC, ELISA Human
HY-P84369A RAB13 Antibody (YA4066)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11522 RAB13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAB13 RGD RGD:620880
Canis familiaris RAB13 VGNC VGNC:45253
Bos taurus RAB13 VGNC VGNC:33621
Mus musculus RAB13 MGD MGI:1927232
Macaca mulatta RAB13 VGNC VGNC:106479
Others RAB13 NCBI