Map2k2 - mitogen activated protein kinase kinase 2 Gene

Also Known as Prkmk2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58960

About Map2k2

Primary_assembly 7: 8,580,905-8,610,243 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 25 phenotypes. Biased expression in Kidney (RPKM 39.2), Muscle (RPKM 261.5) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression and protein phosphorylation. Located in cell cortex and cytosol. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products (1)

mRNA Protein Name
NM_133283.2 NP_579817.1 dual specificity mitogen-activated protein kinase kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
7611406 RGD
enables MAP kinase kinase activity IDA
IDA: Inferred from direct assay
7611406 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16272159 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IGI
IGI: Inferred from genetic interaction
28947594 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
9169613 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
7611406 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
9169613 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
16272159 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k2 Protein Structure

PKc_MEK

PKc_MEK: cd06615 (69 - 387)

  • 0
  • 100
  • 200
  • 300
  • 401 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 2

  • ERK activator kinase 2

  • MAP kinase kinase 2

  • MAPK/ERK kinase 2

  • MAPKK 2

  • MEK 2

  • MEK2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k2 NCBI NCBI:5605