2. Gene
  3. Map2k2 - mitogen activated protein kinase kinase 2 Gene

Map2k2 - mitogen activated protein kinase kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Prkmk2

Gene ID: 58960 | Gene type: protein coding

About Map2k2

Primary_assembly 7: 8,580,905-8,610,243 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 273 orthologues, 8 paralogues and is associated with 25 phenotypes. Biased expression in Kidney (RPKM 39.2), Muscle (RPKM 261.5) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase activity. Involved in negative regulation of gene expression and protein phosphorylation. Located in cell cortex and cytosol. Human ortholog(s) of this gene implicated in cardiofaciocutaneous syndrome 4 and small intestine adenocarcinoma. Orthologous to human MAP2K2 (mitogen-activated protein kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2k2 Products(1)

mRNA Protein Name
NM_133283.2 NP_579817.1 dual specificity mitogen-activated protein kinase kinase 2

Map2k2 Protein Structure

PKc_MEK

PKc_MEK: cd06615 (69 - 387)

  • 0
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  • 401 a.a.
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 2

ERK activator kinase 2

MAP kinase kinase 2

MAPK/ERK kinase 2

MAPKK 2

MEK 2

MEK2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08036 MAP2K2 Human Pre-designed siRNA Set A / Unkown
HY-RS08037 Map2k2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08038 Map2k2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k2 NCBI NCBI:5605