2. Gene
  3. Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Carm1 - coactivator-associated arginine methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Prmt4; m9Bei

Gene ID: 59035 | Gene type: protein coding

About Carm1

Chromosome 9: 21,458,190-21,503,919 forward strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 218 orthologues, 7 paralogues and is associated with 14 phenotypes. Ubiquitous expression in testis adult (RPKM 59.4), limb E14.5 (RPKM 52.7) and 28 other tissues.

Summary

Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including histone H3-R17 methylation; positive regulation of fat cell differentiation; and regulation of intracellular Estrogen Receptor signaling pathway. Acts upstream of or within several processes, including intracellular Estrogen Receptor signaling pathway; regulation of growth plate cartilage chondrocyte proliferation; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; gonad; limb bud; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 Products(3)

mRNA Protein Name
NM_021531.6 NP_067506.2 histone-arginine methyltransferase CARM1 isoform 1
NM_153141.1 NP_694781.1 histone-arginine methyltransferase CARM1 isoform 2
NM_001411233.1 NP_001398162.1 histone-arginine methyltransferase CARM1 isoform 3

Carm1 Protein Structure

CARM1

CARM1: pfam11531 (34 - 138)

SmtA

SmtA: COG0500 (184 - 394)

AdoMet_MTases

AdoMet_MTases: cd02440 (188 - 283)

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  • 608 a.a.
Protein Preferred Names Protein Names

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

protein arginine methyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111109 EZM 2302 Inhibitor 99.59% Unkown
HY-114965 TP-064 Inhibitor 98.35% Unkown
HY-100565 SGC2085 Inhibitor 99.45% Unkown
HY-12759 CARM1-IN-1 Inhibitor ≥95.0% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% Unkown
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.16% Unkown
HY-15214 CARM1-IN-3 Inhibitor 98.90% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor / Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-156152 CARM1 degrader-1 Inhibitor / Unkown
HY-156153 CARM1 degrader-2 Inhibitor / Unkown
HY-158157 ZL-28-6 Inhibitor / Unkown
HY-158158 CARM1-IN-5 Inhibitor / Unkown
HY-161334 CARM1-IN-4 / Unkown
HY-RS01926 CARM1 Human Pre-designed siRNA Set A / Unkown
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carm1 NCBI NCBI:10498