Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Also Known as Prmt4; m9Bei

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59035

About Carm1

Chromosome 9: 21,458,190-21,503,919 forward strand.GRCm39:CM001002.3

This gene has 10 transcripts (splice variants), 218 orthologues, 7 paralogues and is associated with 14 phenotypes. Ubiquitous expression in testis adult (RPKM 59.4), limb E14.5 (RPKM 52.7) and 28 other tissues.

Summary

Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including histone H3-R17 methylation; positive regulation of fat cell differentiation; and regulation of intracellular Estrogen receptor signaling pathway. Acts upstream of or within several processes, including intracellular Estrogen receptor signaling pathway; regulation of growth plate cartilage chondrocyte proliferation; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; gonad; limb bud; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 Products (3)

mRNA Protein Name
NM_021531.6 NP_067506.2 histone-arginine methyltransferase CARM1 isoform 1
NM_153141.1 NP_694781.1 histone-arginine methyltransferase CARM1 isoform 2
NM_001411233.1 NP_001398162.1 histone-arginine methyltransferase CARM1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3R17 methyltransferase activity IDA
IDA: Inferred from direct assay
11341840 MGI
enables histone H3R2 methyltransferase activity IDA
IDA: Inferred from direct assay
17882261 MGI
enables histone H3R26 methyltransferase activity IDA
IDA: Inferred from direct assay
17882261 MGI
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
10381882 MGI
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
17882261 MGI
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
19843527 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10381882 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19843527 MGI
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
10381882 MGI
enables protein-arginine N-methyltransferase activity IDA
IDA: Inferred from direct assay
19843527 MGI
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
IDA: Inferred from direct assay
11341840 MGI
enables transcription cis-regulatory region binding IMP
IMP: Inferred from mutant phenotype
18188184 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
10381882 MGI
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
15616592 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19725955 MGI
acts upstream of or within endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
19725955 MGI
acts upstream of or within estrogen receptor signaling pathway IGI
IGI: Inferred from genetic interaction
12756295 MGI
acts upstream of or within negative regulation of protein binding IDA
IDA: Inferred from direct assay
19725955 MGI
involved in nuclear receptor-mediated steroid hormone signaling pathway IDA
IDA: Inferred from direct assay
14690606 MGI
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
15616592 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19725955 MGI
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
18188184 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15616592 MGI
acts upstream of or within protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
15616592 MGI
acts upstream of or within protein methylation IMP
IMP: Inferred from mutant phenotype
12756295 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10381882 MGI
acts upstream of or within regulation of growth plate cartilage chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
19725955 MGI
involved in regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
19843527 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
22977234 MGI
located in cytosol IDA
IDA: Inferred from direct assay
19843527 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19843527 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
15616592 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Carm1 Protein Structure

CARM1

CARM1: pfam11531 (34 - 138)

SmtA

SmtA: COG0500 (184 - 394)

AdoMet_MTases

AdoMet_MTases: cd02440 (188 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 608 a.a.
Protein Preferred Names Protein Names

histone-arginine methyltransferase CARM1

  • protein arginine N-methyltransferase 4

  • protein arginine methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (35)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-111109 EZM 2302 Inhibitor 99.51% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-100565 SGC2085 Inhibitor 99.46% Unkown
HY-12759 CARM1-IN-1 Inhibitor 95.0% Unkown
HY-21999 tert-Butyl 6-aminocaproate 99.96% Unkown
HY-156152A PROTAC CARM1 degrader-1 hydrochloride Degrader 99.94% Unkown
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.17% Unkown
HY-15214 CARM1-IN-3 Inhibitor 98.90% Unkown
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-163561 CARM1-IN-6 99.59% Unkown
HY-163561A CARM1-IN-6 dihydrochloride Inhibitor 98.44% Unkown
HY-RS01926 CARM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-114510 PRMT/HKMT-IN-1 / Unkown
HY-132885 PARP/EZH2-IN-1 Inhibitor / Unkown
HY-136809 PRMT6-IN-2 Inhibitor / Unkown
HY-156152 PROTAC CARM1 degrader-1 Inhibitor / Unkown
HY-156153 PROTAC CARM1 degrader-2 Inhibitor / Unkown
HY-158157 ZL-28-6 Inhibitor / Unkown
HY-158158 CARM1-IN-5 Inhibitor / Unkown
HY-161334 CARM1-IN-4 / Unkown
HY-172368 PROTAC CARM1/IKZF3 degrader-1 / Unkown
HY-172369 CARM1/IKZF3 ligand 1 Inhibitor / Unkown
HY-181413 PROTAC EZH2 Degrader-44 / Unkown
HY-183653 AK442 Inhibitor / Unkown
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114206 SKI-73 / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown
HY-172370 Thalidomide-NH-C4-Boc / Unkown
HY-W013500 (1-Nitroethene-1,2-diyl)dibenzene Inhibitor 99.05% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carm1 NCBI NCBI:10498